Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread

Chawla, Sharad, Warren, Timothy A., Wockner, Leesa F., Lambie, Duncan L. J., Brown, Ian S., Martin, Thomas P. C., Khanna, Rajiv, Leggatt, Graham R. and Panizza, Benedict J. (2016) Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread. Cancer Immunology, Immunotherapy, 65 2: 213-222. doi:10.1007/s00262-015-1788-z


Author Chawla, Sharad
Warren, Timothy A.
Wockner, Leesa F.
Lambie, Duncan L. J.
Brown, Ian S.
Martin, Thomas P. C.
Khanna, Rajiv
Leggatt, Graham R.
Panizza, Benedict J.
Title Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread
Journal name Cancer Immunology, Immunotherapy   Check publisher's open access policy
ISSN 1432-0851
0340-7004
Publication date 2016-02-01
Sub-type Article (original research)
DOI 10.1007/s00262-015-1788-z
Open Access Status Not Open Access
Volume 65
Issue 2
Start page 213
End page 222
Total pages 10
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Formatted abstract
Spread of head and neck cancer along the cranial nerves is often a lethal complication of this tumour. Current treatment options include surgical resection and/or radiotherapy, but recurrence is a frequent event suggesting that our understanding of this tumour and its microenvironment is incomplete. In this study, we have analysed the nature of the perineural tumour microenvironment by immunohistochemistry with particular focus on immune cells and molecules, which might impair anti-tumour immunity. Moderate to marked lymphocyte infiltrates were present in 58.8 % of the patient cohort including T cells, B cells and FoxP3-expressing T cells. While human leukocyte antigen (HLA) class I and more variably HLA class II were expressed on the tumour cells, this did not associate with patient survival or recurrence. In contrast, galectin-1 staining within lymphocyte areas of the tumour was significantly associated with a poorer patient outcome. Given the known role of galectin-1 in immune suppression, the data suggest that galectin inhibitors might improve the prognosis of patients with perineural spread of cancer.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Medicine Publications
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Sat, 16 Jan 2016, 19:56:28 EST by Dr Graham Leggatt on behalf of UQ Diamantina Institute