New insights into the regulation of innate immunity by caspase-8

Sagulenko, Vitaliya, Lawlor, Kate E. and Vince, James E. (2016) New insights into the regulation of innate immunity by caspase-8. Arthritis Research and Therapy, 18 1: 4.1-4.3. doi:10.1186/s13075-015-0910-0


Author Sagulenko, Vitaliya
Lawlor, Kate E.
Vince, James E.
Title New insights into the regulation of innate immunity by caspase-8
Journal name Arthritis Research and Therapy   Check publisher's open access policy
ISSN 1478-6354
1478-6362
Publication date 2016-01-13
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/s13075-015-0910-0
Open Access Status DOI
Volume 18
Issue 1
Start page 4.1
End page 4.3
Total pages 3
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
Caspase-8 is required for extrinsic apoptosis, but is also central for preventing a pro-inflammatory receptor interacting protein kinase (RIPK) 3-mixed lineage kinase domain-like (MLKL)-dependent cell death pathway termed necroptosis. Despite these critical cellular functions, the impact of capase-8 deletion in the myeloid cell lineage, which forms the basis for innate immune responses, has remained unclear. In a recent article in Arthritis Research & Therapy, Cuda et al. report that myeloid cell-restricted caspase-8 loss leads to a very mild RIPK3-dependent inflammatory phenotype. The presented results suggest that inflammation does not arise exclusively because of RIPK3-mediated necroptotic death but that, in the absence of caspase-8, RIPK1 and RIPK3 enhance microbiome-driven Toll-like receptor-induced pro-inflammatory cytokine production.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 15 Jan 2016, 23:58:00 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences