Pseudomonas aeruginosa: evolution of antimicrobial resistance and implications for therapy

McCarthy, Kate (2015) Pseudomonas aeruginosa: evolution of antimicrobial resistance and implications for therapy. Semin Respir Crit Care Med, 36 1: 44-55. doi:10.1055/s-0034-1396907


Author McCarthy, Kate
Title Pseudomonas aeruginosa: evolution of antimicrobial resistance and implications for therapy
Formatted title
Pseudomonas aeruginosa: evolution of antimicrobial resistance and implications for therapy
Journal name Semin Respir Crit Care Med   Check publisher's open access policy
ISSN 1069-3424
1098-9048
Publication date 2015-02-01
Year available 2015
Sub-type Article (original research)
DOI 10.1055/s-0034-1396907
Open Access Status Not Open Access
Volume 36
Issue 1
Start page 44
End page 55
Total pages 12
Place of publication New York, NY United States
Publisher Thieme Medical Publishers
Language eng
Formatted abstract
Pseudomonas aeruginosa is a formidable pathogen in the infection arena. It is able to easily adapt to the environment which it inhabits and can also colonize and invade the human host to cause serious infections. In 2011, it was responsible for 7.1% of all health care–associated infection in the United States. The morbidity and mortality of both blood stream infections and ventilator-associated pneumonia are significant. On a global scale, we have seen the development of not only multidrug resistance but also extensive and pan drug resistance in this organism. This is often associated with limited clonal types of which we now have epidemiological evidence of spread. With this has come reduced antibiotic treatment options. Consideration of antibiotic infusions, combination therapy, and inhalational therapy has occurred in an attempt to gain the upper ground. Gram-negative resistance has appropriately been described as a global emergency.
Keyword Pseudomonas aeruginosa
Bacteremia
Ventilator-associated pneumonia
Epidemiology
Resistance
Antibiotic treatment
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 15 Jan 2016, 23:06:01 EST by Roheen Gill on behalf of UQ Centre for Clinical Research