High parasite burdens cause liver damage in mice following Plasmodium berghei ANKA infection independently of CD8+ T cell-mediated immune pathology

Haque, Ashraful, Best, Shannon E., Amante, Fiona H., Ammerdorffer, Anne, de Labastida, Fabian, Pereira, Tamara, Ramm, Grant A. and Engwerda, Christian R. (2011) High parasite burdens cause liver damage in mice following Plasmodium berghei ANKA infection independently of CD8+ T cell-mediated immune pathology. Infection and Immunity, 79 5: 1882-1888. doi:10.1128/IAI.01210-10

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Author Haque, Ashraful
Best, Shannon E.
Amante, Fiona H.
Ammerdorffer, Anne
de Labastida, Fabian
Pereira, Tamara
Ramm, Grant A.
Engwerda, Christian R.
Title High parasite burdens cause liver damage in mice following Plasmodium berghei ANKA infection independently of CD8+ T cell-mediated immune pathology
Formatted title
High parasite burdens cause liver damage in mice following Plasmodium berghei ANKA infection independently of CD8+ T cell-mediated immune pathology
Journal name Infection and Immunity   Check publisher's open access policy
ISSN 0019-9567
1098-5522
Publication date 2011-05-01
Year available 2011
Sub-type Article (original research)
DOI 10.1128/IAI.01210-10
Open Access Status File (Publisher version)
Volume 79
Issue 5
Start page 1882
End page 1888
Total pages 7
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Formatted abstract
Infection of C57BL/6 mice with Plasmodium berghei ANKA induces a fatal neurological disease commonly referred to as experimental cerebral malaria. The onset of neurological symptoms and mortality depend on pathogenic CD8+ T cells and elevated parasite burdens in the brain. Here we provide clear evidence of liver damage in this model, which precedes and is independent of the onset of neurological symptoms. Large numbers of parasite-specific CD8+ T cells accumulated in the liver following P. berghei ANKA infection. However, systemic depletion of these cells at various times during infection, while preventing neurological symptoms, failed to protect against liver damage or ameliorate it once established. In contrast, rapid, drug-mediated removal of parasites prevented hepatic injury if administered early and quickly resolved liver damage if administered after the onset of clinical symptoms. These data indicate that CD8+ T cell-mediated immune pathology occurs in the brain but not the liver, while parasite-dependent pathology occurs in both organs during P. berghei ANKA infection. Therefore, we show that P. berghei ANKA infection of C57BL/6 mice is a multiorgan disease driven by the accumulation of parasites, which is also characterized by organ-specific CD8+ T cell-mediated pathology.
Keyword Immunology
Infectious Diseases
Immunology
Infectious Diseases
IMMUNOLOGY
INFECTIOUS DISEASES
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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