Where have all the parasites gone? Modelling early malaria parasite sequestration dynamics

Cromer, Deborah, Best, Shannon E., Engwerda, Christian, Haque, Ashraful and Davenport, Miles (2013) Where have all the parasites gone? Modelling early malaria parasite sequestration dynamics. PLoS ONE, 8 2: . doi:10.1371/journal.pone.0055961

Author Cromer, Deborah
Best, Shannon E.
Engwerda, Christian
Haque, Ashraful
Davenport, Miles
Title Where have all the parasites gone? Modelling early malaria parasite sequestration dynamics
Journal name PLoS ONE   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-02-18
Year available 2013
Sub-type Article (original research)
DOI 10.1371/journal.pone.0055961
Open Access Status DOI
Volume 8
Issue 2
Total pages 11
Place of publication San Francisco, United States
Publisher Public Library of Science
Language eng
Abstract Traditional approaches to measuring the level of malaria infection involve counting the proportion of parasite-infected red blood cells (iRBC) in circulating blood, known as parasitaemia. However, iRBC can also accumulate within the microvasculature of tissues and organs, a process called sequestration. Thus measurements of parasitemia do not necessarily reflect the total parasite burden (TPB). Recent experimental advances have allowed TPB measurements to be made in humans and experimental models. TPB is particularly important because it is the best current predictor of malaria disease severity and death in humans. Understanding the relationship between freely circulating iRBC versus tissue-sequestered iRBC is an important question in infection dynamics. The recent ability to experimentally measure the dynamics of iRBC in blood and tissue during murine malaria provides an exciting potential window into sequestration, but new modeling approaches are clearly required to understand these interactions. We present a model of malaria dynamics during early infection that incorporates iRBC that both circulate in the blood and sequester in tissue microvasculature. We explore the effect that perturbations to the system have on the ratio of the number of iRBC between these compartments, and consider which changes are most consistent with experimental data from mice. Using this model we predict an increase in the clearance rate of sequestered iRBCs around the time when mild symptoms become apparent, but a more pronounced increase in the rate of sequestration of iRBCs associated with the onset of severe malaria symptoms.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 613702
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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