A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei

Easton, Anna, Haque, Ashraful, Chu, Karen, Lukaszewski, Roman and Bancroft, Gregory J. (2007) A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei. Journal of Infectious Diseases, 195 1: 99-107. doi:10.1086/509810


Author Easton, Anna
Haque, Ashraful
Chu, Karen
Lukaszewski, Roman
Bancroft, Gregory J.
Title A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei
Formatted title
A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei
Journal name Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
1537-6613
Publication date 2007-01-01
Sub-type Article (original research)
DOI 10.1086/509810
Open Access Status Not yet assessed
Volume 195
Issue 1
Start page 99
End page 107
Total pages 9
Place of publication Cary, NC, United States
Publisher Oxford University Press
Language eng
Formatted abstract
Inhalation is an important route of infection with Burkholderia pseudomallei, the causative agent of melioidosis. In resistant C57BL/6 mice, activated neutrophils are rapidly recruited to the lungs after intranasal B. pseudomallei infection. Prevention of this response by use of the anti-Gr-1+ cell-depleting monoclonal antibody RB6-8C5 severely exacerbated disease, resulting in an acute lethal infection associated with a 1000-fold increase in lung bacterial loads within 4 days. C57BL/6 interferon (IFN)-γ-/- mice were also acutely susceptible to pulmonary B. pseudomallei infection, dying within 3 days of challenge; this suggests that IFN-γ is essential for control in the lungs and precedes the protective role of neutrophils in resistance. In neutrophil-depleted mice, lung concentrations of tumor necrosis factor (TNF)-α, IFN-γ, and interleukin-6 were decreased by up to 98%. Natural killer cells were the principle source of IFN-γ, and monocytes were the principle source of TNF-α, suggesting that neutrophils play an important indirect role in the generation of the early cytokine environment in the lungs.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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