Understanding the contribution of surface roughness and hydrophobic modification of silica nanoparticles to enhanced therapeutic protein delivery

Niu, Yuting, Yu, Meihua, Meka, Anand, Liu, Yang, Zhang, Jun, Yang, Yannan and Yu, Chengzhong (2015) Understanding the contribution of surface roughness and hydrophobic modification of silica nanoparticles to enhanced therapeutic protein delivery. Journal of Materials Chemistry B, 4 2: 212-219. doi:10.1039/c5tb01911g


Author Niu, Yuting
Yu, Meihua
Meka, Anand
Liu, Yang
Zhang, Jun
Yang, Yannan
Yu, Chengzhong
Title Understanding the contribution of surface roughness and hydrophobic modification of silica nanoparticles to enhanced therapeutic protein delivery
Journal name Journal of Materials Chemistry B   Check publisher's open access policy
ISSN 2050-750X
2050-7518
Publication date 2015-11-01
Year available 2015
Sub-type Article (original research)
DOI 10.1039/c5tb01911g
Open Access Status Not yet assessed
Volume 4
Issue 2
Start page 212
End page 219
Total pages 8
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Language eng
Abstract Intracellular protein delivery holds great promise for cancer therapy. In this work, the individual and combined contribution of the surface roughness and hydrophobic modification (octadecyl-group) of silica nanoparticles has been studied in a number of events for cellular delivery of therapeutic proteins, including loading capacity, release behaviour, cellular uptake and endo/lysosomal escape. Both surface roughening and hydrophobic modification enhance the protein adsorption capacity and sustained release, while the contribution from the surface roughness is higher for loading capacity and hydrophobic modification is more effective for sustained protein release. Both structural parameters improve the cellular uptake performance; however the difference in the contribution is cell type-dependent. Only the hydrophobic modification shows a contribution to endo/lysosomal escape, independent of the surface topography. Octadecyl-functionalized rough silica nanoparticles thus show the best performance in therapeutic protein (RNase A) delivery, causing significant cell viability inhibition in different cancer cells among all groups under study.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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