Fetal programming and gestational diabetes mellitus

Monteiro, Lara J., Norman, Jane E., Rice, Gregory E. and Illanes, Sebastian E. (2015) Fetal programming and gestational diabetes mellitus. Placenta, 48 8: S54-S60. doi:10.1016/j.placenta.2015.11.015

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Author Monteiro, Lara J.
Norman, Jane E.
Rice, Gregory E.
Illanes, Sebastian E.
Title Fetal programming and gestational diabetes mellitus
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
0143-4004
Publication date 2015-12-12
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.placenta.2015.11.015
Open Access Status File (Author Post-print)
Volume 48
Issue 8
Start page S54
End page S60
Total pages 7
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Subject 2743 Reproductive Medicine
2729 Obstetrics and Gynaecology
1309 Developmental Biology
Abstract Gestational diabetes mellitus is defined by new-onset glucose intolerance during pregnancy. About 2–5% of all pregnant women develop gestational diabetes during their pregnancies and the prevalence has increased considerably during the last decade. This metabolic condition is manifested when pancreatic β-cells lose their ability to compensate for increased insulin resistance during pregnancy, however, the pathogenesis of the disease remains largely unknown. Gestational diabetes is strongly associated with adverse pregnancy outcome as well as with long-term adverse effects on the offspring which likely occurs due to epigenetic modifications of the fetal genome. In the current review we address gestational diabetes and the short and long term complications for both mothers and offspring focusing on the importance of fetal programming in conferring risk of developing diseases in adulthood.
Keyword Epigenetics
Fetal programming
Gestational diabetes mellitus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
 
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