Fluorescent knock-in mice to decipher the physiopathological role of G protein-coupled receptors

Glikmann-Johnston, Yifat, Saling, Michael M., Reutens, David C. and Stout, Julie C. (2015) Fluorescent knock-in mice to decipher the physiopathological role of G protein-coupled receptors. Frontiers in Pharmacology, 6 289: . doi:10.3389/fphar.2015.00289


Author Glikmann-Johnston, Yifat
Saling, Michael M.
Reutens, David C.
Stout, Julie C.
Title Fluorescent knock-in mice to decipher the physiopathological role of G protein-coupled receptors
Journal name Frontiers in Pharmacology   Check publisher's open access policy
ISSN 1663-9812
Publication date 2015-12-10
Year available 2015
Sub-type Article (original research)
DOI 10.3389/fphar.2015.00289
Open Access Status DOI
Volume 6
Issue 289
Total pages 10
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2016
Language eng
Formatted abstract
Spatial cognition is fundamental for survival in the topographically complex environments inhabited by humans and other animals. The hippocampus, which has a central role in spatial cognition, is characterized by high concentration of serotonin (5-hydroxytryptamine; 5-HT) receptor binding sites, particularly of the 1A receptor (5-HT1A) subtype. This review highlights converging evidence for the role of hippocampal 5-HT1A receptors in spatial learning and memory. We consider studies showing that activation or blockade of the 5-HT1A receptors using agonists or antagonists, respectively, lead to changes in spatial learning and memory. For example, pharmacological manipulation to induce 5-HT release, or to block 5-HT uptake, have indicated that increased extracellular 5-HT concentrations maintain or improve memory performance. In contrast, reduced levels of 5-HT have been shown to impair spatial memory. Furthermore, the lack of 5-HT1A receptor subtype in single gene knockout mice is specifically associated with spatial memory impairments. These findings, along with evidence from recent cognitive imaging studies using positron emission tomography (PET) with 5-HT1A receptor ligands, and studies of individual genetic variance in 5-HT1A receptor availability, strongly suggests that 5-HT, mediated by the 5-HT1A receptor subtype, plays a key role in spatial learning and memory.
Keyword Serotonin
5-HT1A
Receptor
Hippocampus
Spatial cognition
Memory
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Centre for Advanced Imaging Publications
 
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