Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update

Stoffer, Michaela A., Schoels, Monika M., Smolen, Josef S., Aletaha, Daniel, Breedveld, Ferdinand C., Burmester, Gerd, Bykerk, Vivian, Dougados, Maxime, Emery, Paul, Haraoui, Boulos, Gomez-Reino, Juan, Kvien, Tore K., Nash, Peter, Navarro-Compan, Victoria, Scholte-Voshaar, Marieke, van Vollenhoven, Ronald, van der Heijde, Desiree and Stamm, Tanja A. (2016) Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update. Annals of the Rheumatic Diseases, 75 1: 16-22. doi:10.1136/annrheumdis-2015-207526


Author Stoffer, Michaela A.
Schoels, Monika M.
Smolen, Josef S.
Aletaha, Daniel
Breedveld, Ferdinand C.
Burmester, Gerd
Bykerk, Vivian
Dougados, Maxime
Emery, Paul
Haraoui, Boulos
Gomez-Reino, Juan
Kvien, Tore K.
Nash, Peter
Navarro-Compan, Victoria
Scholte-Voshaar, Marieke
van Vollenhoven, Ronald
van der Heijde, Desiree
Stamm, Tanja A.
Title Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update
Journal name Annals of the Rheumatic Diseases   Check publisher's open access policy
ISSN 0003-4967
1468-2060
Publication date 2016-01-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1136/annrheumdis-2015-207526
Open Access Status DOI
Volume 75
Issue 1
Start page 16
End page 22
Total pages 7
Place of publication London, United Kingdom
Publisher BMJ Publishing Group
Language eng
Abstract A systematic literature review (SLR; 2009-2014) to compare a target-oriented approach with routine management in the treatment of rheumatoid arthritis (RA) to allow an update of the treat-to-target recommendations.
Formatted abstract
Objective A systematic literature review (SLR; 2009–2014) to compare a target-oriented approach with routine management in the treatment of rheumatoid arthritis (RA) to allow an update of the treat-to-target recommendations.
Methods Two SLRs focused on clinical trials employing a treatment approach targeting a specific clinical outcome were performed. In addition to testing clinical, functional and/or structural changes as endpoints, comorbidities, cardiovascular risk, work productivity and education as well as patient self-assessment were investigated. The searches covered MEDLINE, EMBASE, Cochrane databases and Clinicaltrial.gov for the period between 2009 and 2012 and separately for the period of 2012 to May of 2014.
Results Of 8442 citations retrieved in the two SLRs, 176 articles underwent full-text review. According to predefined inclusion/exclusion criteria, six articles were included of which five showed superiority of a targeted treatment approach aiming at least at low-disease activity versus routine care; in addition, publications providing supportive evidence were also incorporated that aside from expanding the evidence provided by the above six publications allowed concluding that a target-oriented approach leads to less comorbidities and cardiovascular risk and better work productivity than conventional care.
Conclusions The current study expands the evidence that targeting low-disease activity or remission in the management of RA conveys better outcomes than routine care.
Keyword Control treatment strategy
Clinical-practice
Activity score
Remission
Disease
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 18475
Institutional Status UQ
Additional Notes Published online 19 May 2015

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
 
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