Motor imagery in Parkinson's disease: A PET study

Cunnington, R, Egan, GF, OSullivan, JD, Hughes, AJ, Bradshaw, JL and Colebatch, JG (2001) Motor imagery in Parkinson's disease: A PET study. Movement Disorders, 16 5: 849-857. doi:10.1002/mds.1181


Author Cunnington, R
Egan, GF
OSullivan, JD
Hughes, AJ
Bradshaw, JL
Colebatch, JG
Title Motor imagery in Parkinson's disease: A PET study
Journal name Movement Disorders   Check publisher's open access policy
ISSN 0885-3185
Publication date 2001-01-01
Year available 2001
Sub-type Article (original research)
DOI 10.1002/mds.1181
Open Access Status Not yet assessed
Volume 16
Issue 5
Start page 849
End page 857
Total pages 9
Place of publication New York
Publisher Wiley-liss
Language eng
Abstract We used positron emission tomography (PET) with O-15-labelled water to record patterns of cerebral activation in six patients with Parkinson's disease (PD), studied when clinically off and after turning on as a result of dopaminergic stimulation. They were asked to imagine a Finger opposition movement performed with their right hand. externally paced at a rate of 1 Hz. Trials alternating between motor imagery and rest were measured. A pilot study of three age-matched controls was also performed. We chose the task as a robust method of activating the supplementary motor area (SMA), defects of which have been reported in PD. The PD patients showed normal de-rees of activation of the SMA (proper) when both off and on. Significant activation with imagining movement also occurred in the ipsilateral inferior parietal cortex (both off and when on) and ipsilateral premotor cortex (when off only). The patients showed significantly greater activation of the rostral anterior cingulate and significantly less activation of the left lingual gyrus and precuneus when performing the task on compared with their performance when off. PD patients when imagining movement and off showed less activation of several sites including the right dorsolateral prefrontal cortex (DLPFC) when compared to the controls performing the same task. No significant differences from controls were present when the patients imagined when on. Our results are consistent with other studies showing deficits of pre-SMA function in PD with preserved function of the SMA proper. In addition to the areas of reduced activation (anterior cingulate, DLPFC), there were also sites of activation (ipsilateral premotor and inferior parietal cortex) previously reported as locations of compensatory overactivity for PD patients performing similar tasks. Both failure of activation and compensatory changes a-re likely to contribute to the motor deficit in PD. (C) 2001 Movement Disorder Society.
Keyword Clinical Neurology
Motor Imagery
Movement Preparation
Parkinson's Disease
Supplementary Motor Area
Positron Emission Tomography
Movement-related Potentials
Cerebral Blood-flow
Externally Triggered Movements
Basal Ganglia
Lateral Premotor
Cortical Areas
Macaque Monkey
Activation
Voluntary
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Mon, 13 Aug 2007, 22:37:25 EST