Spatiotemporal aspects of Hendra virus infection in pteropid bats (flying-foxes) in Eastern Australia

Field, Hume, Jordan, David, Edson, Daniel, Morris, Stephen, Melville, Debra, Parry-Jones, Kerryn, Broos, Alice, Divljan, Anja, McMichael, Lee, Davis, Rodney, Kung, Nina, Kirkland, Peter and Smith, Craig (2015) Spatiotemporal aspects of Hendra virus infection in pteropid bats (flying-foxes) in Eastern Australia. PloS One, 10 12: . doi:10.1371/journal.pone.0144055


Author Field, Hume
Jordan, David
Edson, Daniel
Morris, Stephen
Melville, Debra
Parry-Jones, Kerryn
Broos, Alice
Divljan, Anja
McMichael, Lee
Davis, Rodney
Kung, Nina
Kirkland, Peter
Smith, Craig
Title Spatiotemporal aspects of Hendra virus infection in pteropid bats (flying-foxes) in Eastern Australia
Journal name PloS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2015-12-01
Sub-type Article (original research)
DOI 10.1371/journal.pone.0144055
Open Access Status DOI
Volume 10
Issue 12
Total pages 14
Place of publication San Francisco, United States
Publisher Public Library of Science
Language eng
Abstract Hendra virus (HeV) causes highly lethal disease in horses and humans in the eastern Australian states of Queensland (QLD) and New South Wales (NSW), with multiple equine cases now reported on an annual basis. Infection and excretion dynamics in pteropid bats (flying-foxes), the recognised natural reservoir, are incompletely understood. We sought to identify key spatial and temporal factors associated with excretion in flying-foxes over a 2300 km latitudinal gradient from northern QLD to southern NSW which encompassed all known equine case locations. The aim was to strengthen knowledge of Hendra virus ecology in flying-foxes to improve spillover risk prediction and exposure risk mitigation strategies, and thus better protect horses and humans. Monthly pooled urine samples were collected from under roosting flying-foxes over a three-year period and screened for HeV RNA by quantitative RT-PCR. A generalised linear model was employed to investigate spatiotemporal associations with HeV detection in 13,968 samples from 27 roosts. There was a non-linear relationship between mean HeV excretion prevalence and five latitudinal regions, with excretion moderate in northern and central QLD, highest in southern QLD/northern NSW, moderate in central NSW, and negligible in southern NSW. Highest HeV positivity occurred where black or spectacled flying-foxes were present; nil or very low positivity rates occurred in exclusive grey-headed flying-fox roosts. Similarly, little red flying-foxes are evidently not a significant source of virus, as their periodic extreme increase in numbers at some roosts was not associated with any concurrent increase in HeV detection. There was a consistent, strong winter seasonality to excretion in the southern QLD/northern NSW and central NSW regions. This new information allows risk management strategies to be refined and targeted, mindful of the potential for spatial risk profiles to shift over time with changes in flying-fox species distribution.
Keyword New South Wales
Morbillivirus pneumonia
Horses
Humans
Transmission
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Article # e0144055

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Veterinary Science Publications
 
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