Molecular and translational classifications of DAMPs in immunogenic cell death

Garg, Abhishek D., Galluzzi, Lorenzo, Apetoh, Lionel, Baert, Thais, Birge, Raymond B., Bravo-San Pedro, Jose Manuel, Breckpot, Karine, Brough, David, Chaurio, Ricardo, Cirone, Mara, Coosemans, An, Coulie, Pierre G., De Ruysscher, Dirk, Dini, Luciana, Witte, Peter de, Dudek-Peric, Aleksandra M., Faggioni, Alberto, Fucikova, Jitka, Gaipl, Udo S., Golab, Jakub, Gougeon, Marie-Lise, Hamblin, Michael R., Hemminki, Akseli, Herrmann, Martin, Hodge, James W., Kepp, Oliver, Kroemer, Guido, Krysko, Dmitri V., Land, Walter G., Madeo, Frank, Manfredi, Angelo A., Mattarollo, Stephen R., Maueroder, Christian, Merendino, Nicolo, Multhoff, Gabriele, Pabst, Thomas, Ricci, Jean-Ehrland, Riganti, Chiara, Romano, Erminia, Rufo, Nicole, Smyth, Mark J., Sonnemann, Jurgen, Spisek, Radek, Stagg, John, Vacchelli, Erika, Vandenabeele, Peter, Vandenberk, Lien, Van den Eynde, Benoit J., Van Gool, Stefaan, Velotti, Francesca, Zitvogel, Laurence and Agostinis, Patrizia (2015) Molecular and translational classifications of DAMPs in immunogenic cell death. Frontiers in Immunology, 6 588: . doi:10.3389/fimmu.2015.00588

Author Garg, Abhishek D.
Galluzzi, Lorenzo
Apetoh, Lionel
Baert, Thais
Birge, Raymond B.
Bravo-San Pedro, Jose Manuel
Breckpot, Karine
Brough, David
Chaurio, Ricardo
Cirone, Mara
Coosemans, An
Coulie, Pierre G.
De Ruysscher, Dirk
Dini, Luciana
Witte, Peter de
Dudek-Peric, Aleksandra M.
Faggioni, Alberto
Fucikova, Jitka
Gaipl, Udo S.
Golab, Jakub
Gougeon, Marie-Lise
Hamblin, Michael R.
Hemminki, Akseli
Herrmann, Martin
Hodge, James W.
Kepp, Oliver
Kroemer, Guido
Krysko, Dmitri V.
Land, Walter G.
Madeo, Frank
Manfredi, Angelo A.
Mattarollo, Stephen R.
Maueroder, Christian
Merendino, Nicolo
Multhoff, Gabriele
Pabst, Thomas
Ricci, Jean-Ehrland
Riganti, Chiara
Romano, Erminia
Rufo, Nicole
Smyth, Mark J.
Sonnemann, Jurgen
Spisek, Radek
Stagg, John
Vacchelli, Erika
Vandenabeele, Peter
Vandenberk, Lien
Van den Eynde, Benoit J.
Van Gool, Stefaan
Velotti, Francesca
Zitvogel, Laurence
Agostinis, Patrizia
Title Molecular and translational classifications of DAMPs in immunogenic cell death
Journal name Frontiers in Immunology   Check publisher's open access policy
ISSN 1664-3224
Publication date 2015-11-20
Year available 2015
Sub-type Article (original research)
DOI 10.3389/fimmu.2015.00588
Open Access Status DOI
Volume 6
Issue 588
Total pages 24
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Abstract The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall immunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called “damage-associated molecular patterns” (DAMPs). The emission of DAMPs and other immunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishment of immunological memory. Although ICD has been characterized with increased precision since its discovery, several questions remain to be addressed. Here, we summarize and tabulate the main molecular, immunological, preclinical, and clinical aspects of ICD, in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation.
Keyword Anti-tumor immunity
Molecular medicine
Patient prognosis
Translational medicine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
UQ Diamantina Institute Publications
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