Associations of serum adiponectin with markers of cardio-metabolic disease risk in Indigenous Australian adults with good health, diabetes and chronic kidney disease

Hughes, J.T., O'Dea, K., Piera, K., Barzi, F., Cass, A., Hoy, W.E., MacIsaac, R.J. and Maple-Brown, L.J. (2015) Associations of serum adiponectin with markers of cardio-metabolic disease risk in Indigenous Australian adults with good health, diabetes and chronic kidney disease. Obesity Research and Clinical Practice, 10 6: 659-672. doi:10.1016/j.orcp.2015.11.008


Author Hughes, J.T.
O'Dea, K.
Piera, K.
Barzi, F.
Cass, A.
Hoy, W.E.
MacIsaac, R.J.
Maple-Brown, L.J.
Title Associations of serum adiponectin with markers of cardio-metabolic disease risk in Indigenous Australian adults with good health, diabetes and chronic kidney disease
Journal name Obesity Research and Clinical Practice   Check publisher's open access policy
ISSN 1878-0318
1871-403X
Publication date 2015-12-05
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.orcp.2015.11.008
Open Access Status Not yet assessed
Volume 10
Issue 6
Start page 659
End page 672
Total pages 14
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 2712 Endocrinology, Diabetes and Metabolism
2916 Nutrition and Dietetics
Abstract The higher serum adiponectin concentrations observed in females are often attributed to differences in adiposity or sex hormones. There is little data describing adiponectin in Indigenous Australians, and no studies examining its association with cardio-metabolic disease risk markers and chronic kidney disease (CKD). Aim To describe the relationship of serum adiponectin with cardio-metabolic disease risk markers and kidney function in a community-based sample of Indigenous Australian adults, with particular reference to sex-specific differences. Methods A cross-sectional analysis of a community-based volunteer sample of 548 Indigenous Australian adults (62% female), stratified into five cardio-metabolic risk groups ranging from good health (strata-1) to high cardio-metabolic risk and low measured glomerular filtration rate (mGFR, <60 ml/min/1.73 m) (strata-5). We examined serum adiponectin concentrations with cardio-metabolic risk markers, albuminuria and mGFR. Results Indigenous Australian females had a lower than expected adiponectin concentration (3.5 μg/ml), which was higher than males in strata 1–4 (as in other populations), but not in strata-5 (mGFR < 60, p = 0.19), and higher leptin: adiponectin ratio than other populations (7.8 ng/μg – strata-1, healthy females; 12.2 ng/μg – strata-3, females with diabetes and mGFR ≥ 90). Female-gender, HDL-cholesterol (positive), mGFR and waist: hip ratio (WHR) (inverse) were independently associated with log-adiponectin when mGFR ≥ 60; when mGFR < 60, female-gender was associated with 0.27 units lower log-adiponectin. Conclusion Female-gender was not associated with higher adiponectin concentrations in Indigenous Australians with mGFR < 60 ml/min/1.73 m. High WHR was frequent in both genders, and inversely associated with adiponectin. Longitudinal studies are needed to examine relationships of serum adiponectin, obesity and cardiovascular disease events in Indigenous Australians.
Formatted abstract
The higher serum adiponectin concentrations observed in females are often attributed to differences in adiposity or sex hormones. There is little data describing adiponectin in Indigenous Australians, and no studies examining its association with cardio-metabolic disease risk markers and chronic kidney disease (CKD).

Aim

To describe the relationship of serum adiponectin with cardio-metabolic disease risk markers and kidney function in a community-based sample of Indigenous Australian adults, with particular reference to sex-specific differences.

Methods

A cross-sectional analysis of a community-based volunteer sample of 548 Indigenous Australian adults (62% female), stratified into five cardio-metabolic risk groups ranging from good health (strata-1) to high cardio-metabolic risk and low measured glomerular filtration rate (mGFR, <60 ml/min/1.73 m2) (strata-5). We examined serum adiponectin concentrations with cardio-metabolic risk markers, albuminuria and mGFR.

Results

Indigenous Australian females had a lower than expected adiponectin concentration (3.5 μg/ml), which was higher than males in strata 1–4 (as in other populations), but not in strata-5 (mGFR < 60, p = 0.19), and higher leptin: adiponectin ratio than other populations (7.8 ng/μg – strata-1, healthy females; 12.2 ng/μg – strata-3, females with diabetes and mGFR ≥ 90). Female-gender, HDL-cholesterol (positive), mGFR and waist: hip ratio (WHR) (inverse) were independently associated with log-adiponectin when mGFR ≥ 60; when mGFR < 60, female-gender was associated with 0.27 units lower log-adiponectin.

Conclusion

Female-gender was not associated with higher adiponectin concentrations in Indigenous Australians with mGFR < 60 ml/min/1.73 m2. High WHR was frequent in both genders, and inversely associated with adiponectin. Longitudinal studies are needed to examine relationships of serum adiponectin, obesity and cardiovascular disease events in Indigenous Australians.
Keyword Indigenous
Obesity
Adiponectin
Diabetes
Chronic kidney disease
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 545202
ECF 1092576
490307
605837
1078477
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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