A systematic review and meta-analysis of management options for adults who respond poorly to hepatitis B vaccination

David, Michael C., Ha, Sung Hyun, Paynter, Stuart and Lau, Colleen (2015) A systematic review and meta-analysis of management options for adults who respond poorly to hepatitis B vaccination. Vaccine, 33 48: 6564-6569. doi:10.1016/j.vaccine.2015.09.051


Author David, Michael C.
Ha, Sung Hyun
Paynter, Stuart
Lau, Colleen
Title A systematic review and meta-analysis of management options for adults who respond poorly to hepatitis B vaccination
Journal name Vaccine   Check publisher's open access policy
ISSN 1873-2518
0264-410X
Publication date 2015-11-27
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.vaccine.2015.09.051
Open Access Status Not yet assessed
Volume 33
Issue 48
Start page 6564
End page 6569
Total pages 6
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
An estimated 5–10% of adults do not seroconvert after a three-dose primary course of hepatitis B vaccines, and are considered non-responders. Many approaches have been used to induce immunity in healthy adult non-responders, but few studies have compared their relative effectiveness. We conducted a systematic review and meta-analysis of seroconversion rates after additional doses of four approaches: 20 mcg or 40 mcg intramuscular (IM), and 5 mcg or 20 mcg intradermal (ID). The search identified 13 articles encompassing 16 studies (N = 1067) that met the eligibility criteria. Seroconversion rates after additional doses of each approach were pooled and estimated. After one additional dose, the four approaches produced very similar seroconversion rates and we did not find any evidence to support the use of 40 mcg IM in healthy adults.
Keyword Hepatitis B
Meta-analysis
Seroconversion rate
Vaccination
Immunisation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Public Health Publications
Child Health Research Centre Publications
 
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