Proposal of Gleason-like grading system of canine prostate carcinoma in veterinary pathology practice

Palmieri, Chiara and Grieco, Valeria (2015) Proposal of Gleason-like grading system of canine prostate carcinoma in veterinary pathology practice. Research in Veterinary Science, 103 11-15. doi:10.1016/j.rvsc.2015.09.004

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Author Palmieri, Chiara
Grieco, Valeria
Title Proposal of Gleason-like grading system of canine prostate carcinoma in veterinary pathology practice
Journal name Research in Veterinary Science   Check publisher's open access policy
ISSN 1532-2661
0034-5288
Publication date 2015-12-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.rvsc.2015.09.004
Open Access Status File (Author Post-print)
Volume 103
Start page 11
End page 15
Total pages 5
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Subject 3400 Veterinary
Abstract Gleason grading – the most useful predictor of prognosis for prostate cancer in men – was updated at a 2005 consensus conference by the International Society of Urological Pathology. Since Gleason-like growth patterns have been recognised in dogs, this study aimed to apply the modified Gleason grading to 45 canine prostate carcinomas. A single primary growth pattern was observed in 28 cases, a secondary pattern in 11 cases and a tertiary pattern in 6 cases. Cribriform, solid and small acinar/ductal were the most common primary, secondary and tertiary morphological patterns, respectively. The highest Gleason score (GS10) was obtained in 46.7% of cases. Nine of 14 metastasizing cases were classified as GS10. Gleason pattern 5 was present in 33 of cases. This study suggests that the modified Gleason grading, based on specific histological growth patterns existing in canine prostate carcinomas, may be accepted as a grading system for histopathology in the practice settings in order to complete the clinical assessment for the best management of the patient.
Keyword Dog
Prostate
Carcinoma
Gleason grading
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Veterinary Science Publications
 
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