Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Artigas, Maria Soler, Wain, Louise V., Miller, Suzanne, Kheirallah, Abdul Kader, Huffman, Jennifer E., Ntalla, Ioanna, Shrine, Nick, Obeidat, Ma'en, Trochet, Holly, McArdle, Wendy L., Alves, Alexessander Couto, Hui, Jennie, Zhao, Jing Hua, Joshi, Peter K., Teumer, Alexander, Albrecht, Eva, Imboden, Medea, Rawal, Rajesh, Lopez, Lorna M., Marten, Jonathan, Enroth, Stefan, Surakka, Ida, Polasek, Ozren, Lyytikainen, Leo-Pekka, Granell, Raquel, Hysi, Pirro G., Flexeder, Claudia, Mahajan, Anubha, Beilby, John, Bosse, Yohan, Brandsma, Corry-Anke, Campbell, Harry, Gieger, Christian, Glaser, Sven, Gonzalez, Juan R., Grallert, Harald, Hammond, Chris J., Harris, Sarah E., Hartikainen, Anna-Liisa, Heliovaara, Markku, Henderson, John, Hocking, Lynne, Horikoshi, Momoko, Hutri-Kahonen, Nina, Ingelsson, Erik, Johansson, Asa, Kemp, John P., Kolcic, Ivana, Kumar, Ashish, Lind, Lars, Melen, Erik, Musk, Arthur W., Navarro, Pau, Nickle, David C., Padmanabhan, Sandosh, Raitakari, Olli T., Ried, Janina S., Ripatti, Samuli, Schulz, Holger, Scott, Robert A., Sin, Don D., Starr, John M., Vinuela, Ana, Volzke, Henry, Wild, Sarah H., Wright, Alan F., Zemunik, Tatijana, Jarvis, Deborah L., Spector, Tim D., Evans, David M., Lehtimaki, Terho, Vitart, Veronique, Kahonen, Mika, Gyllensten, Ulf, Rudan, Igor, Deary, Ian J., Karrasch, Stefan, Probst-Hensch, Nicole M., Heinrich, Joachim, Stubbe, Beate, Wilson, James F., Wareham, Nicholas J., James, Alan L., Morris, Andrew P., Jarvelin, Marjo-Ritta, Hayward, Caroline, Sayers, Ian, Strachan, David P., Hall, Ian P., Tobin, Martin D., Deloukas, Panos, Hansell, Anna L., Hubbard, Richard, Jackson, Victoria E., Marchini, Jonathan, Pavord, Ian, Thomson, Neil C. and Zeggini, Eleftheria (2015) Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6 8658: 1-12. doi:10.1038/ncomms9658


Author Artigas, Maria Soler
Wain, Louise V.
Miller, Suzanne
Kheirallah, Abdul Kader
Huffman, Jennifer E.
Ntalla, Ioanna
Shrine, Nick
Obeidat, Ma'en
Trochet, Holly
McArdle, Wendy L.
Alves, Alexessander Couto
Hui, Jennie
Zhao, Jing Hua
Joshi, Peter K.
Teumer, Alexander
Albrecht, Eva
Imboden, Medea
Rawal, Rajesh
Lopez, Lorna M.
Marten, Jonathan
Enroth, Stefan
Surakka, Ida
Polasek, Ozren
Lyytikainen, Leo-Pekka
Granell, Raquel
Hysi, Pirro G.
Flexeder, Claudia
Mahajan, Anubha
Beilby, John
Bosse, Yohan
Brandsma, Corry-Anke
Campbell, Harry
Gieger, Christian
Glaser, Sven
Gonzalez, Juan R.
Grallert, Harald
Hammond, Chris J.
Harris, Sarah E.
Hartikainen, Anna-Liisa
Heliovaara, Markku
Henderson, John
Hocking, Lynne
Horikoshi, Momoko
Hutri-Kahonen, Nina
Ingelsson, Erik
Johansson, Asa
Kemp, John P.
Kolcic, Ivana
Kumar, Ashish
Lind, Lars
Melen, Erik
Musk, Arthur W.
Navarro, Pau
Nickle, David C.
Padmanabhan, Sandosh
Raitakari, Olli T.
Ried, Janina S.
Ripatti, Samuli
Schulz, Holger
Scott, Robert A.
Sin, Don D.
Starr, John M.
Vinuela, Ana
Volzke, Henry
Wild, Sarah H.
Wright, Alan F.
Zemunik, Tatijana
Jarvis, Deborah L.
Spector, Tim D.
Evans, David M.
Lehtimaki, Terho
Vitart, Veronique
Kahonen, Mika
Gyllensten, Ulf
Rudan, Igor
Deary, Ian J.
Karrasch, Stefan
Probst-Hensch, Nicole M.
Heinrich, Joachim
Stubbe, Beate
Wilson, James F.
Wareham, Nicholas J.
James, Alan L.
Morris, Andrew P.
Jarvelin, Marjo-Ritta
Hayward, Caroline
Sayers, Ian
Strachan, David P.
Hall, Ian P.
Tobin, Martin D.
Deloukas, Panos
Hansell, Anna L.
Hubbard, Richard
Jackson, Victoria E.
Marchini, Jonathan
Pavord, Ian
Thomson, Neil C.
Zeggini, Eleftheria
Title Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2015-12-04
Year available 2015
Sub-type Article (original research)
DOI 10.1038/ncomms9658
Open Access Status DOI
Volume 6
Issue 8658
Start page 1
End page 12
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1600 Chemistry
1300 Biochemistry, Genetics and Molecular Biology
3100 Physics and Astronomy
Abstract Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
Formatted abstract
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10−8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID ETM/55
CZB/4/505
G1001799
098017
R01 MH063706
092731
R01 EY018246
R01 HL087679
1R01EY018246
G1000861
079895
5R01MH63706:02
MC_PC_12010
1RL1MH083268-01
MR/L01341X/1
MR/K026992/1
G0500539
MC_UU_12015/1
MC_U106179471
MR/N01104X/1
U01 DK062418
WT 084703MA
MC_PC_U127592696
G0501942
MC_UU_12013/4
CZD/16/6/4
MC_PC_U127561128
G0902313
WT090532
BB/F019394/1
068545/Z/02
5R01HL087679-02
RL1 MH083268
G1002319
SRF/01/010
WT064890
076113/B/04/Z
G0000934
G0600705
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Diamantina Institute - Open Access Collection
Official 2016 Collection
UQ Diamantina Institute Publications
 
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