The impact of acupuncture on neurological recovery in spinal cord injury: a systematic review and meta-analysis

Ma, Ruijie, Liu, Xin, Clark, Justin, Williams, Gail M. and Doi, Suhail A. (2015) The impact of acupuncture on neurological recovery in spinal cord injury: a systematic review and meta-analysis. Journal of Neurotrauma, 32 24: 1943-1957. doi:10.1089/neu.2014.3866

Author Ma, Ruijie
Liu, Xin
Clark, Justin
Williams, Gail M.
Doi, Suhail A.
Title The impact of acupuncture on neurological recovery in spinal cord injury: a systematic review and meta-analysis
Journal name Journal of Neurotrauma   Check publisher's open access policy
ISSN 1557-9042
Publication date 2015-12-11
Year available 2015
Sub-type Article (original research)
DOI 10.1089/neu.2014.3866
Open Access Status Not Open Access
Volume 32
Issue 24
Start page 1943
End page 1957
Total pages 15
Place of publication New Rochelle, NY United States
Publisher Mary Ann Liebert, Inc. Publishers
Language eng
Subject 2728 Clinical Neurology
Abstract Spinal cord injury (SCI) has become a significant social and economic burden for patients and their families. The effect of acupuncture on neurological recovery in individuals with SCI remains inconclusive despite previous studies and meta-analyses. The aim of the current study was to perform a more rigorous systematic review and bias-adjusted meta-analysis of studies so that the overall impact of acupuncture on neurological recovery in SCI can be determined. Randomized controlled trials (RCTs) only were included and were searched for in seven databases through to August 2014. Four key outcomes were assessed: neurological recovery, motor function, sensory function, and functional recovery. Several statistical approaches were compared, models were tested for robustness using sensitivity analysis, and results are presented as weighted mean difference (WMD) or standardized mean difference (SMD) for continuous outcomes and relative risk (RR) for binary outcomes. The included studies' susceptibility to bias was also assessed. A total of 12 studies were included after exclusions were applied. Heterogeneity was evident among the studies included. Pooled analyses showed that acupuncture may have a beneficial effect on neurological recovery (RRs: 1.28, 95% confidence interval [CI]: 1.12–1.50), motor function (WMD: 6.86, 95% CI: 0.41–13.31), and functional recovery (SMD: 0.88, 95% CI: 0.56–1.21) and all statistical approaches concurred. Sensitivity analyses suggested that the smaller studies (sample size <30), those with acute disease, and studies that used varying acupuncture sessions demonstrated a larger magnitude of effect. However, studies were generally of poor quality and publication bias favoring positive studies was evident. Therefore, the benefit of acupuncture we report is by no means definitive and well-designed future studies are recommended to confirm this.
Keyword Acupuncture
Systematic review
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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