Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution

Briggs, James A., Wolvetang, Ernst J., Mattick, John S., Rinn, John L. and Barry, Guy (2015) Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution. Neuron, 88 5: 861-877. doi:10.1016/j.neuron.2015.09.045


Author Briggs, James A.
Wolvetang, Ernst J.
Mattick, John S.
Rinn, John L.
Barry, Guy
Title Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution
Journal name Neuron   Check publisher's open access policy
ISSN 1097-4199
0896-6273
Publication date 2015-12-02
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.neuron.2015.09.045
Open Access Status Not Open Access
Volume 88
Issue 5
Start page 861
End page 877
Total pages 17
Place of publication Cambridge, MA, United States
Publisher Cell Press
Language eng
Subject 2800 Neuroscience
Abstract Only relatively recently has it become clear that mammalian genomes encode tens of thousands of long non-coding RNAs (lncRNAs). A striking 40% of these are expressed specifically in the brain, where they show precisely regulated temporal and spatial expression patterns. This begs the question, what is the functional role of these many lncRNA transcripts in the brain? Here we canvass a growing number of mechanistic studies that have elucidated central roles for lncRNAs in the regulation of nervous system development and function. We also survey studies indicating that neurological and psychiatric disorders may ensue when these mechanisms break down. Finally, we synthesize these insights with evidence from comparative genomics to argue that lncRNAs may have played important roles in brain evolution, by virtue of their abundant sequence innovation in mammals and plausible mechanistic connections to the adaptive processes that occurred recently in the primate and human lineages.
Keyword Embryonic Stem-Cells
Natural Antisense Transcripts
Human Brain Evolution
Dendritic Bc1 Rna
Alzheimers-Disease
Gene-Expression
Messenger-Rna
Human Genome
In-Vivo
Neuronal Differentiation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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