Investigating the properties and hydrolysis ability of poly-lactic acid/chitosan nanocomposites using polycaprolactone

Thu Trang, Nguyen Thi, Chinh, Nguyen Thuy, Mai Thanh, Dinh Thi, Xuan Hang, To Thi, Giang, Nguyen Vu, Hoang, Thai, Quan, Pham Minh, Giang, Le Duc, Thai, Nguyen Viet and Lawrence, Geoffrey (2015) Investigating the properties and hydrolysis ability of poly-lactic acid/chitosan nanocomposites using polycaprolactone. Journal of Nanoscience and Nanotechnology, 15 12: 9585-9590. doi:10.1166/jnn.2015.10498


Author Thu Trang, Nguyen Thi
Chinh, Nguyen Thuy
Mai Thanh, Dinh Thi
Xuan Hang, To Thi
Giang, Nguyen Vu
Hoang, Thai
Quan, Pham Minh
Giang, Le Duc
Thai, Nguyen Viet
Lawrence, Geoffrey
Title Investigating the properties and hydrolysis ability of poly-lactic acid/chitosan nanocomposites using polycaprolactone
Journal name Journal of Nanoscience and Nanotechnology   Check publisher's open access policy
ISSN 1533-4880
1533-4899
Publication date 2015-12-01
Year available 2015
Sub-type Article (original research)
DOI 10.1166/jnn.2015.10498
Open Access Status Not Open Access
Volume 15
Issue 12
Start page 9585
End page 9590
Total pages 6
Place of publication Valencia, CA United States
Publisher American Scientific Publishers
Language eng
Subject 1502 Bioengineering
1600 Chemistry
2204 Biomedical Engineering
2500 Materials Science
3104 Condensed Matter Physics
Abstract Poly-lactic acid (PLA) has been widely applied in the medical field (in biomedicines such as medical capsules, surgical sutures and suture wounds) owing to its high biodegradability, good biocompatibility and ability to be dissolved in common solvents. Chitosan (CS) is an abundant polysaccharide and a cationic polyelectrolyte present in nature. In this study, the combination of PLA and CS has been used to form PLA/CS nanocomposites having the advantages of both the original components. To enhance the dispersibility and compatibility between PLA and CS in the PLA/CS nanocomposites, polycaprolactone (PCL) is added as a compatibilizer. The Fourier Transform Infrared spectroscopies prove the existence of the interactions of PCL with PLA and CS. A more regular dispersion of CS of 200-400 nm particle size, is observed in the PLA matrix of the PLA/CS nanocomposites containing PCL, through the Field Emission Scanning Electron Microscopy images. The appearance of one glass transition temperature (T) value of PLA/CS/PCL nanocomposites occuring between the T values of PLA and CS in DSC diagrams confirms the improvement in the compatibility between PLA and CS, due to the presence of PCL. The TGA result shows that PCL plays an important role in enhancing the thermal stability of PLA/CS/PCL nanocomposites. The hydrolysis of PLA/CS/PCL nanocomposites in alkaline and phosphate buffer solutions was investigated. The obtained results show that the PLA/CS/PCL nanocomposites have slower hydrolysis ability than the PLA/CS composites.
Formatted abstract
Poly-lactic acid (PLA) has been widely applied in the medical field (in biomedicines such as medical capsules, surgical sutures and suture wounds) owing to its high biodegradability, good biocompatibility and ability to be dissolved in common solvents. Chitosan (CS) is an abundant polysaccharide and a cationic polyelectrolyte present in nature. In this study, the combination of PLA and CS has been used to form PLA/CS nanocomposites having the advantages of both the original components. To enhance the dispersibility and compatibility between PLA and CS in the PLA/CS nanocomposites, polycaprolactone (PCL) is added as a compatibilizer. The Fourier Transform Infrared spectroscopies prove the existence of the interactions of PCL with PLA and CS. A more regular dispersion of CS of 200–400 nm particle size, is observed in the PLA matrix of the PLA/CS nanocomposites containing PCL, through the Field Emission Scanning Electron Microscopy images. The appearance of one glass transition temperature (T g) value of PLA/CS/PCL nanocomposites occuring between the T g values of PLA and CS in DSC diagrams confirms the improvement in the compatibility between PLA and CS, due to the presence of PCL. The TGA result shows that PCL plays an important role in enhancing the thermal stability of PLA/CS/PCL nanocomposites. The hydrolysis of PLA/CS/PCL nanocomposites in alkaline and phosphate buffer solutions was investigated. The obtained results show that the PLA/CS/PCL nanocomposites have slower hydrolysis ability than the PLA/CS composites.
Keyword Chitosan
Glass transition temperature
Hydrolysis
Poly-lactic acid
Polycaprolactone
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Australian Institute for Bioengineering and Nanotechnology Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 27 Dec 2015, 10:29:15 EST by System User on behalf of Aust Institute for Bioengineering & Nanotechnology