Core-cone structured monodispersed mesoporous silica nanoparticles with ultra-large cavity for protein delivery

Xu, Chun, Yu, Meihua, Noonan, Owen, Zhang, Jun, Song, Hao, Zhang, Hongwei, Lei, Chang, Niu, Yuting, Huang, Xiaodan, Yang, Yannan and Yu, Chengzhong (2015) Core-cone structured monodispersed mesoporous silica nanoparticles with ultra-large cavity for protein delivery. Small, 11 44: 5949-5955. doi:10.1002/smll.201501449


Author Xu, Chun
Yu, Meihua
Noonan, Owen
Zhang, Jun
Song, Hao
Zhang, Hongwei
Lei, Chang
Niu, Yuting
Huang, Xiaodan
Yang, Yannan
Yu, Chengzhong
Title Core-cone structured monodispersed mesoporous silica nanoparticles with ultra-large cavity for protein delivery
Journal name Small   Check publisher's open access policy
ISSN 1613-6810
1613-6829
Publication date 2015-10-01
Year available 2015
Sub-type Article (original research)
DOI 10.1002/smll.201501449
Open Access Status Not yet assessed
Volume 11
Issue 44
Start page 5949
End page 5955
Total pages 7
Place of publication Weinheim, Germany
Publisher Wiley-VCH Verlag
Language eng
Subject 1305 Biotechnology
2502 Biomaterials
2201 Engineering (miscellaneous)
Abstract A new type of monodispersed mesoporous silica nanoparticles with a core-cone structure (MSN-CC) has been synthesized. The large cone-shaped pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to the flower dahlia. MSN-CC has a large pore size of 45 nm and a high pore volume of 2.59 cm g. MSN-CC demonstrates a high loading capacity of large proteins and successfully delivers active β-galactosidase into cells, showing their potential as efficient nanocarriers for the cellular delivery of proteins with large molecular weights. Dahlia-like silica: A new type of monodispersed mesoporous silica nanoparticle with core-cone structures (MSN-CC) is synthesized. The cone-shaped large pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to a dahlia. MSN-CC demonstrates successful intracellular delivery of large protein of β-galactosidase (β-gal, 119 kDa) and retains its protein enzymatic activity.
Formatted abstract
A new type of monodispersed mesoporous silica nanoparticles with a core–cone structure (MSN-CC) has been synthesized. The large cone-shaped pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to the flower dahlia. MSN-CC has a large pore size of 45 nm and a high pore volume of 2.59 cm3 g−1. MSN-CC demonstrates a high loading capacity of large proteins and successfully delivers active β-galactosidase into cells, showing their potential as efficient nanocarriers for the cellular delivery of proteins with large molecular weights.
Keyword Biologically-Active Proteins
Intracellular Delivery
Drug-Delivery
Nanocarriers
Transduction
Nanospheres
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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