Angiotensin receptors: Interpreters of pathophysiological angiotensinergic stimulis

Karnik, Sadashiva S., Unal, Hamiyet, Kemp, Jacqueline R., Tirupula, Kalyan C., Eguchi, Satoru, Vanderheyden, Patrick M. L. and Thomas, Walter G. (2015) Angiotensin receptors: Interpreters of pathophysiological angiotensinergic stimulis. Pharmacological Reviews, 67 4: 754-819. doi:10.1124/pr.114.010454

Author Karnik, Sadashiva S.
Unal, Hamiyet
Kemp, Jacqueline R.
Tirupula, Kalyan C.
Eguchi, Satoru
Vanderheyden, Patrick M. L.
Thomas, Walter G.
Title Angiotensin receptors: Interpreters of pathophysiological angiotensinergic stimulis
Journal name Pharmacological Reviews   Check publisher's open access policy
ISSN 1521-0081
Publication date 2015-10-01
Year available 2015
Sub-type Article (original research)
DOI 10.1124/pr.114.010454
Open Access Status Not Open Access
Volume 67
Issue 4
Start page 754
End page 819
Total pages 66
Place of publication Bethesda, MD, United States
Publisher American Society for Pharmacology and Experimental Therapeutics
Language eng
Formatted abstract
The renin angiotensin system (RAS) produced hormone peptides regulate many vital body functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states. Nearly half of humanity today would likely benefit from modern drugs targeting these receptors. The receptors for RAS peptides consist of three G-protein–coupled receptors—the angiotensin II type 1 receptor (AT1 receptor), the angiotensin II type 2 receptor (AT2 receptor), the MAS receptor—and a type II trans-membrane zinc protein—the candidate angiotensin IV receptor (AngIV binding site). The prorenin receptor is a relatively new contender for consideration, but is not included here because the role of prorenin receptor as an independent endocrine mediator is presently unclear. The full spectrum of biologic characteristics of these receptors is still evolving, but there is evidence establishing unique roles of each receptor in cardiovascular, hemodynamic, neurologic, renal, and endothelial functions, as well as in cell proliferation, survival, matrix-cell interaction, and inflammation. Therapeutic agents targeted to these receptors are either in active use in clinical intervention of major common diseases or under evaluation for repurposing in many other disorders. Broad-spectrum influence these receptors produce in complex pathophysiological context in our body highlights their role as precise interpreters of distinctive angiotensinergic peptide cues. This review article summarizes findings published in the last 15 years on the structure, pharmacology, signaling, physiology, and disease states related to angiotensin receptors. We also discuss the challenges the pharmacologist presently faces in formally accepting newer members as established angiotensin receptors and emphasize necessary future developments.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
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