The impact of vitamin D deficiency on behaviour and brain function in rodents

Overeem, Kathie, Eyles, Darryl W., McGrath, John J. and Burne, Thomas H. J. (2016) The impact of vitamin D deficiency on behaviour and brain function in rodents. Current Opinion in Behavioral Sciences, 7 47-52. doi:10.1016/j.cobeha.2015.11.012

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Author Overeem, Kathie
Eyles, Darryl W.
McGrath, John J.
Burne, Thomas H. J.
Title The impact of vitamin D deficiency on behaviour and brain function in rodents
Journal name Current Opinion in Behavioral Sciences   Check publisher's open access policy
ISSN 2352-1546
Publication date 2016-02-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.cobeha.2015.11.012
Open Access Status File (Author Post-print)
Volume 7
Start page 47
End page 52
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
Vitamin D deficiency has been proposed as an environmental risk factor for several neurological disorders. To investigate the biological plausibility of this risk factor, vitamin D (DVD) deficiency rodent models have been used to examine the impact of DVD deficiency on neurobiology and behaviour. The majority of these studies have taken a developmental stance and examined the impact of vitamin D deficiency during gestation on the adult behaviour of the offspring. In the rat, the most constant behavioural phenotypes include hyperlocomotion in response to novelty, psychostimulant sensitively, impulsivity, and augmented motivation. However, in the mouse increased exploratory behaviour and motivational alterations are observed. Researchers have also examined the affect of adult vitamin D deficiency in rodents. The resultant behavioural alterations include increased exploratory activity and impulsivity in the rat, while increased hyperlocomotion and sensory sensitivity is observed in the mouse. Thus, both the developing and adult brain are sensitive to dietary vitamin D status. However, the behavioural alterations are subtle and influenced by factors such as species, strain, sex, and age. This illustrates the amenability and complexity of neurobiological systems that are influenced by vitamin D status. Nonetheless, with increasing evidence for epidemiological associations between neuropathological disorders and vitamin D, carefully designed rodent models are well placed as a tool to explore the neurobiological and behavioural domains that may be sensitive to vitamin D.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published online 26 November 2015

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2016 Collection
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Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
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Created: Mon, 21 Dec 2015, 21:55:25 EST by Susan Day on behalf of Scholarly Communication and Digitisation Service