Mutation screening of the c-MYB negative regulatory domain in acute and chronic myeloid leukaemia

Lutwyche, JK, Keough, RA, Hughes, TP and Gonda, TJ (2001) Mutation screening of the c-MYB negative regulatory domain in acute and chronic myeloid leukaemia. British Journal of Haematology, 114 3: 632-634. doi:10.1046/j.1365-2141.2001.02966.x


Author Lutwyche, JK
Keough, RA
Hughes, TP
Gonda, TJ
Title Mutation screening of the c-MYB negative regulatory domain in acute and chronic myeloid leukaemia
Journal name British Journal of Haematology   Check publisher's open access policy
ISSN 0007-1048
Publication date 2001-01-01
Sub-type Article (original research)
DOI 10.1046/j.1365-2141.2001.02966.x
Open Access Status Not Open Access
Volume 114
Issue 3
Start page 632
End page 634
Total pages 3
Place of publication Oxford
Publisher Blackwell Science Ltd
Language eng
Abstract Over-expression of the c-myb gene and expression of activated forms of myb are known to transform haemopoietic cells, particularly cells of the myeloid lineage. Truncations or mutations that disrupt the negative regulatory domain (NRD) of the Myb protein confer an increased ability to transform cells. Although it has proved difficult to link mutations in c-MYB to human leukaemia, no studies investigating the presence of mutations within the c-MYB NRD have been reported. Therefore, we have performed mutational analysis of this region, using polymerase chain reaction-single-stranded conformation polymorphism and sequence analysis, in 26 patients with acute or chronic myeloid leukaemia, No mutations were detected, indicating that mutation of this region of the Myb protein is not common in the pathogenesis or progression of these diseases.
Keyword Hematology
Acute Myeloid Leukaemia
Chronic Myeloid Leukaemia
C-myb
Proto-oncogene
Single-stranded Conformation Polymorphism
Cell Lymphomas
Transformation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Mon, 13 Aug 2007, 22:32:49 EST