Improving treatment of neurodevelopmental disorders: recommendations based on preclinical studies

Homberg, Judith R., Kyzar, Evan J., Stewart, Adam Michael, Nguyen, Michael, Poudel, Manoj K., Echevarria, David J., Collier, Adam D., Gaikwad, Siddharth, Klimenko, Viktor M., Norton, William, Pittman, Julian, Nakamura, Shun, Koshiba, Mamiko, Yamanouchi, Hideo, Apryatin, Sergey A., Scattoni, Maria, Diamond, David M., Ullmann, Jeremy F.P., Parker, Matthew O., Brown, Richard E., Song, Cai and Kalueff, Allan V. (2015) Improving treatment of neurodevelopmental disorders: recommendations based on preclinical studies. Expert Opinion on Drug Discovery, 11 1: 11-25. doi:10.1517/17460441.2016.1115834

Author Homberg, Judith R.
Kyzar, Evan J.
Stewart, Adam Michael
Nguyen, Michael
Poudel, Manoj K.
Echevarria, David J.
Collier, Adam D.
Gaikwad, Siddharth
Klimenko, Viktor M.
Norton, William
Pittman, Julian
Nakamura, Shun
Koshiba, Mamiko
Yamanouchi, Hideo
Apryatin, Sergey A.
Scattoni, Maria
Diamond, David M.
Ullmann, Jeremy F.P.
Parker, Matthew O.
Brown, Richard E.
Song, Cai
Kalueff, Allan V.
Title Improving treatment of neurodevelopmental disorders: recommendations based on preclinical studies
Journal name Expert Opinion on Drug Discovery   Check publisher's open access policy
ISSN 1746-045X
Publication date 2015-12-03
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1517/17460441.2016.1115834
Open Access Status Not yet assessed
Volume 11
Issue 1
Start page 11
End page 25
Total pages 15
Place of publication Oxfordshire, United Kingdom
Publisher Taylor and Francis
Language eng
Formatted abstract
Introduction: Neurodevelopmental disorders (NDDs) are common and severely debilitating. Their chronic nature and reliance on both genetic and environmental factors makes studying NDDs and their treatment a challenging task.

Areas covered: Herein, the authors discuss the neurobiological mechanisms of NDDs, and present recommendations on their translational research and therapy, outlined by the International Stress and Behavior Society. Various drugs currently prescribed to treat NDDs also represent a highly diverse group. Acting on various neurotransmitter and physiological systems, these drugs often lack specificity of action, and are commonly used to treat multiple other psychiatric conditions. There has also been relatively little progress in the development of novel medications to treat NDDs. Based on clinical, preclinical and translational models of NDDs, our recommendations cover a wide range of methodological approaches and conceptual strategies.

Expert opinion: To improve pharmacotherapy and drug discovery for NDDs, we need a stronger emphasis on targeting multiple endophenotypes, a better dissection of genetic/epigenetic factors or “hidden heritability,” and a careful consideration of potential developmental/trophic roles of brain neurotransmitters. The validity of animal NDD models can be improved through discovery of novel (behavioral, physiological and neuroimaging) biomarkers, applying proper environmental enrichment, widening the spectrum of model organisms, targeting developmental trajectories of NDD-related behaviors and comorbid conditions beyond traditional NDDs. While these recommendations cannot be addressed all in once, our increased understanding of NDD pathobiology may trigger innovative cross-disciplinary research expanding beyond traditional methods and concepts.
Keyword ADHD
Animal models
Neurodevelopmental disorders
Translational research
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
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