The effects of supercritical carbon dioxide processing on progesterone dispersion systems: a multivariate study

Falconer, James R., Wen, Jingyuan, Zargar-Shoshtari, Sara, Chen, John J., Mohammed, Farid, Chan, Judy and Alany, Raid G. (2012) The effects of supercritical carbon dioxide processing on progesterone dispersion systems: a multivariate study. AAPS PharmSciTech, 13 4: 1255-1265. doi:10.1208/s12249-012-9850-z


Author Falconer, James R.
Wen, Jingyuan
Zargar-Shoshtari, Sara
Chen, John J.
Mohammed, Farid
Chan, Judy
Alany, Raid G.
Title The effects of supercritical carbon dioxide processing on progesterone dispersion systems: a multivariate study
Journal name AAPS PharmSciTech   Check publisher's open access policy
ISSN 1530-9932
Publication date 2012-01-01
Year available 2012
Sub-type Article (original research)
DOI 10.1208/s12249-012-9850-z
Open Access Status Not Open Access
Volume 13
Issue 4
Start page 1255
End page 1265
Total pages 11
Place of publication New York, NY, United States
Publisher Springer
Language eng
Subject 3003 Pharmaceutical Science
Abstract The aim of this work was to investigate the effects of supercritical carbon dioxide (SC-CO2) processing on the release profiles of progesterone (PGN) and Gelucire 44/14 dispersion systems. A fractional factorial design was conducted for optimization of the particles from gas-saturated suspension (PGSS) method and formulation parameters and evaluating the effects of three independent responses: PGSS process yield, in vitro dissolution extent after 20 min (E 20) and t 1/2 for prepared PGN dispersion systems. The experimental domain included seven factors measured at two levels to determine which factors represent the greatest amount of variation, hence the most influence on the resulting PGN dispersion systems. Variables tested were temperature (A) and pressure (B) of the supercritical fluid, sample loading (C), SC-CO2 processing time (D), sonication (E), drug-to-excipient ratio (F) and orifice diameter into the expansion chamber (G). The analysis of variance showed that the factors tested had significant effects on the responses (p value <0.05). It was found that the optimum values of the PGSS process are higher pressure (186 bar), higher temperature (60 C), a longer processing time (30 min) and lower PGN-to-excipient ratio of 1:10. The corresponding processing yield was 94.7%, extent of PGN dissolution after 20 min was 85.6% and the t 1/2 was 17.7 min. The results suggest that Gelucire 44/14-based dispersion systems might represent a promising formulation for delivery of PGN. The preparation of PGN-loaded Gelucire 44/14 dispersion systems from a PGSS method can be optimized by factorial design experimentation.
Keyword Factorial design experiment
In vitro dissolution
Optimization
Particles from gas-saturated suspensions (PGSS)
Process yield
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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