Evaluation of progesterone permeability from supercritical fluid processed dispersion systems

Falconer, James R., Wen, Jingyuan, Zargar-Shoshtari, Sara, Chen, John J., Farid, Mohammed, El Maghraby, Gamal M. and Alany, Raid G. (2014) Evaluation of progesterone permeability from supercritical fluid processed dispersion systems. Pharmaceutical Development and Technology, 19 2: 238-246. doi:10.3109/10837450.2013.769570

Author Falconer, James R.
Wen, Jingyuan
Zargar-Shoshtari, Sara
Chen, John J.
Farid, Mohammed
El Maghraby, Gamal M.
Alany, Raid G.
Title Evaluation of progesterone permeability from supercritical fluid processed dispersion systems
Journal name Pharmaceutical Development and Technology   Check publisher's open access policy
ISSN 1097-9867
Publication date 2014-01-01
Sub-type Article (original research)
DOI 10.3109/10837450.2013.769570
Open Access Status Not Open Access
Volume 19
Issue 2
Start page 238
End page 246
Total pages 9
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Informa Healthcare
Language eng
Subject 3003 Pharmaceutical Science
Abstract The aim of this study was to investigate the permeability of unique dispersion systems prepared by supercritical fluid (SCF) processing, to deliver bioidentical progesterone (PGN) across mouse skin. Semisolid dispersions of PGN were made up of either polyethylene glycol (PEG) 400/4000, Gelucire 44/14, d-a-tocopheryl PEG 1000 succinate (TPGS), tanscutol P or myritol 318. SCF dispersion systems were compared with various control formulations; a market cream, aqueous suspension, and three conventionally prepared dispersions comelted, cosolvent and physically mixed systems. The permeability coefficient in the absence or presence of a permeation enhancer was evaluated using ex vivo mouse skin. The permeation study results for the TPGS/myritol/transcutol P dispersion system prepared using supercritical carbon dioxide (SC-CO 2) had a two-fold improvement in transdermal permeation over 24 h compared to the control formulation, 245.7 and 126 μgcm-2, respectively (p value<0.05). In this study, the skin integrity and morphology was also investigated for changes due to the formulation constituents using histological examination and Fourier transform infrared spectroscopy. The particles from the gas-saturated suspension method and SC-CO2 together with TPGS/myritol/transcutol P may offer potential advantages over the available cream on the market based on the vastly improved lag time and flux of PGN across the skin.
Keyword Gelucire 44/14
Myritol 318
Particles from gas-saturated suspension
Polyethylene glycol
Transcutol P
Vitamin E (TPGS)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
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