Utility of inflammatory markers in predicting the aetiology of pneumonia in children

Elemraid, Mohamed A., Rushton, Stephen P., Thomas, Matthew F., Spencer, David A., Gennery, Andrew R. and Clark, Julia E. (2014) Utility of inflammatory markers in predicting the aetiology of pneumonia in children. Diagnostic Microbiology and Infectious Disease, 79 4: 458-462. doi:10.1016/j.diagmicrobio.2014.04.006

Author Elemraid, Mohamed A.
Rushton, Stephen P.
Thomas, Matthew F.
Spencer, David A.
Gennery, Andrew R.
Clark, Julia E.
Title Utility of inflammatory markers in predicting the aetiology of pneumonia in children
Journal name Diagnostic Microbiology and Infectious Disease   Check publisher's open access policy
ISSN 1879-0070
Publication date 2014-08-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.diagmicrobio.2014.04.006
Open Access Status DOI
Volume 79
Issue 4
Start page 458
End page 462
Total pages 5
Place of publication Philadelphia, PA United States
Publisher Elsevier
Language eng
Abstract We aimed to investigate the diagnostic value of applying cut-off levels of inflammatory markers and to develop a prediction model for differentiation between bacterial and viral infections in paediatric community-acquired pneumonia based on C-reactive protein (CRP), neutrophil, and white cell counts (WCC). Amongst 401 children, those with bacterial pneumonia were older than those with viral pneumonia (P< 0.001). Compared to viral, bacterial infections had a higher median CRP level (P< 0.001), whereas WCC and neutrophil count were not different. Bacterial infections were associated with higher CRP >80 mg/L than viral infections (P= 0.001), but levels <20 mg/L were not discriminatory (P= 0.254). Receiver operating characteristic curve of the model for differentiating bacterial from viral pneumonia based on age, CRP, and neutrophil count produced area under the curve of 0.894 with 75.7% sensitivity and 89.4% specificity. This aetiological discriminant prediction model is a potentially useful tool in clinical management and epidemiological studies of paediatric pneumonia.
Keyword C-reactive protein
White cells
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 0887X1-4479
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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