Aetiology of paediatric pneumonia after the introduction of pneumococcal conjugate vaccine

Elemraid, Mohamed A., Sails, Andrew D., Eltringham, Gary J. A., Perry, John D., Rushton, Stephen P., Spencer, David A., Thomas, Matthew F., Eastham, Katherine M., Hampton, Fiona, Gennery, Andrew R. and Clark, Julia E. (2013) Aetiology of paediatric pneumonia after the introduction of pneumococcal conjugate vaccine. European Respiratory Journal, 42 6: 1595-1603. doi:10.1183/09031936.00199112

Author Elemraid, Mohamed A.
Sails, Andrew D.
Eltringham, Gary J. A.
Perry, John D.
Rushton, Stephen P.
Spencer, David A.
Thomas, Matthew F.
Eastham, Katherine M.
Hampton, Fiona
Gennery, Andrew R.
Clark, Julia E.
Title Aetiology of paediatric pneumonia after the introduction of pneumococcal conjugate vaccine
Journal name European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
Publication date 2013-12-01
Year available 2013
Sub-type Article (original research)
DOI 10.1183/09031936.00199112
Open Access Status Not yet assessed
Volume 42
Issue 6
Start page 1595
End page 1603
Total pages 9
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Language eng
Formatted abstract
We describe the aetiology of community-acquired pneumonia in children before and after the introduction of the pneumococcal conjugate vaccination (PCV) programme in 2006. Prospective studies were conducted in 2001-2002 (pre-vaccine) and 2009-2011 (post-vaccine) of children aged 0-16 years with radiologically confirmed pneumonia seen in hospital. Investigations included culture, serology, immunofluorescence antibody and urine antigen testing, with an increased use of PCR assays and expanded panels of pathogens in the post-vaccine study. 241 and 160 children were enrolled in the pre- and post-vaccine studies, respectively (73% aged <5 years). Identification of a causative pathogen was higher post-vaccination (61%) than pre-vaccination (48.5%) (p=0.019). Rates of bacterial infections were not different between post- and pre-vaccine studies (17.5% versus 24%, p=0.258). Viral (31%) and mixed (12.5%) infections were found more often postvaccination (19.5%, p=0.021) than pre-vaccination (5%, p=0.015). Rates of identified pneumococcal infections were comparable between pre- and post-vaccine studies (14.7% versus 17.4%, p=0.557). Diagnosis of pneumococcal infection post-vaccination improved when PCR was used compared to culture (21.6% versus 6%, p=0.0004). Serotypes included in PCV13 but not PCV7 were identified in 75% (18 out of 24) post-vaccination. Infection with nonvaccine pneumococcal serotypes continues to be a significant cause of pneumonia in children in the UK. Copyright
Keyword Respiratory System
Respiratory System
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 0887X1-4479
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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