Risk factors for the development of pleural empyema in children

Elemraid, Mohamed A., Thomas, Matthew F., Blain, Alasdair P., Rushton, Stephen P., Spencer, David A., Gennery, Andrew R. and Clark, Julia E. (2015) Risk factors for the development of pleural empyema in children. Pediatric Pulmonology, 50 7: 721-726. doi:10.1002/ppul.23041


Author Elemraid, Mohamed A.
Thomas, Matthew F.
Blain, Alasdair P.
Rushton, Stephen P.
Spencer, David A.
Gennery, Andrew R.
Clark, Julia E.
Title Risk factors for the development of pleural empyema in children
Journal name Pediatric Pulmonology   Check publisher's open access policy
ISSN 1099-0496
8755-6863
Publication date 2015-07-01
Year available 2015
Sub-type Article (original research)
DOI 10.1002/ppul.23041
Open Access Status DOI
Volume 50
Issue 7
Start page 721
End page 726
Total pages 6
Place of publication Hoboken, NJ, United States
Publisher John Wiley and Sons
Language eng
Formatted abstract
Pediatric pleural empyema has increased substantially over the past 20 years and reasons for this rise remain not fully explained. We investigated potential risk factors for the development of empyema in children by examining a cohort of patients with community-acquired pneumonia. Demographic, clinical, and socioeconomic characteristics, use of Ibuprofen prior to presentation and selected potential epidemiological risk factors were analyzed. Data were collected from a prospective etiological study of radiologically confirmed pneumonia in hospitalized children aged ≤16 years. One hundred sixty children were enrolled; 56% were male and 69% aged <5 years. Empyema complication developed in 40 (25%) children. Children with empyema were more frequently prescribed Ibuprofen prior to admission to hospital than those without (82% vs. 46.2%; OR 1.94, 97.5% credible interval 0.80–3.18). Bacterial infection was strongly associated with the development of empyema (OR 3.34, 97.5% credible interval 1.70–5.14). In contrast age, sex, maternal age, parental smoking, level of socioeconomic status, nursery attendance, asthma, household characteristics (bedrooms and number of occupants) were not significantly different between groups. In conclusion, children with pneumonia who developed empyema had more often received Ibuprofen prior to hospitalization and confirmed bacterial infection. We suggest a population-based study involving both primary and secondary care settings would help to investigate the role of Ibuprofen use in modulating the course of disease in children with pneumonia.
Keyword Empyema
Ibuprofen
Pediatrics
Pneumonia
Risk factors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
Child Health Research Centre Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
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