Cephazolin and Gentamicin are stable in lactate-buffered Fresenius peritoneal Dialysate for seven days at room temperature

Singh, Gillian K. Balbir, Wolley, Martin J., Laycock, Valmai C., Voss, David M., Middleditch, Martin J. and Marshall, Mark R. (2014) Cephazolin and Gentamicin are stable in lactate-buffered Fresenius peritoneal Dialysate for seven days at room temperature. Peritoneal Dialysis International, 34 2: 227-243. doi:10.3747/pdi.2013.00013


Author Singh, Gillian K. Balbir
Wolley, Martin J.
Laycock, Valmai C.
Voss, David M.
Middleditch, Martin J.
Marshall, Mark R.
Title Cephazolin and Gentamicin are stable in lactate-buffered Fresenius peritoneal Dialysate for seven days at room temperature
Journal name Peritoneal Dialysis International   Check publisher's open access policy
ISSN 1718-4304
0896-8608
Publication date 2014-03-01
Year available 2014
Sub-type Article (original research)
DOI 10.3747/pdi.2013.00013
Open Access Status DOI
Volume 34
Issue 2
Start page 227
End page 243
Total pages 17
Place of publication Milton, ON Canada
Publisher Multimed
Language eng
Abstract Peritoneal dialysis (PD) peritonitis is a common complication of PD and is associated with significant morbidity and mortality (1). Treatment involves intraperitoneal delivery of antibiotics, which, for this condition, is superior to the intravenous route (2). Outpatient treatment involves loading antibiotics into bags of dialysate, which are then self-administered. However, some patients are unable to load the antibiotics themselves and therefore rely on pre-loaded bags provided to them by health care staff. Treatment for PD peritonitis is usually required for no less than 14 days, and it is desirable to pre-load at least several days’ worth of bags for convenient outpatient therapy (3). That pre-loading in turn depends on the stability of the required antibiotic in solution under conditions of home storage. However, relevant data on antibiotic stability is limited to just some of the available PD solutions and containers (4-7). Guidelines, such as those published by the International Society for Peritoneal Dialysis provide information about the stability and compatibility of various antibiotics in peritoneal dialysate, although they note the limited data for specific PD solutions and suggest the need for further study (3). It has also been suggested by others that data obtained from experiments in one solution or system cannot be extrapolated to another (4). A commonly used PD system is the polyvinyl chloride twin-bagged lactate-buffered glucose-based solution from Fresenius (ANDY-Plus/Disc: Fresenius Medical Care, Bad Homburg, Germany). The stability of antibiotics in this system has not been widely studied and cannot be confirmed by the manufacturer. The aim of the present study was therefore to assess the stability of cephazolin and gentamicin in that dialysate under conditions that simulate up to 7 days of home storage, to ensure effective and convenient use for outpatient treatment of PD peritonitis.
Keyword Urology & Nephrology
Urology & Nephrology
UROLOGY & NEPHROLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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