Heroin overdose: causes and consequences

Warner-Smith, Matthew, Darke, Shane, Lynskey, Michael and Hall, Wayne (2001) Heroin overdose: causes and consequences. Addiction, 96 8: 1113-1125. doi:10.1046/j.1360-0443.2001.96811135.x

Author Warner-Smith, Matthew
Darke, Shane
Lynskey, Michael
Hall, Wayne
Title Heroin overdose: causes and consequences
Journal name Addiction   Check publisher's open access policy
ISSN 0965-2140
Publication date 2001-08-01
Year available 2001
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1046/j.1360-0443.2001.96811135.x
Open Access Status Not yet assessed
Volume 96
Issue 8
Start page 1113
End page 1125
Total pages 13
Place of publication Abingdon, England
Publisher Blackwell
Language eng
Subject 11 Medical and Health Sciences
1117 Public Health and Health Services
Abstract Over the past decade fatal opioid overdose has emerged as a major public health issue internationally. This paper examines the risk factors for overdose from a biomedical perspective. while significant risk factors for opioid overdose fatality are well recognized, the mechanism of fatal overdose remains unclear. Losses of tolerance and concomitant use of alcohol and other CNS depressants clearly play a major role in fatality; howeve, such risk factors do not account for the strong age and gender patterns observed consistently among victims of overdose. There is evidence that systemic disease may be more prevalent in users at greatest risk of overdose. We hypothesize that pulmonary and hepatic dysfunction resulting from such disease may increase susceptibility to both fatal and non-fatal overdose. Sequelae of non-fatal overdose are recognized in the clinical literature but few epidemiological data exist describing the burden of morbidity arising from such sequelae. The potential for overdose to cause persisting morbidity is reviewed.
Keyword Substance Abuse
Injecting Drug-users
Morphine Concentrations
Cohort Trends
Pulmonary Complications
Nonfatal Overdose
Narcotic Addicts
Opioid Overdose
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 200 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 13 Aug 2007, 22:29:26 EST