Inflammasomes in COPD and neutrophilic asthma

Kim. Richard Y., Pinkerton, James W., Gibson, Peter G., Cooper, Matthew A., Horvat, Jay C. and Hansbro, Philip M. (2015) Inflammasomes in COPD and neutrophilic asthma. Thorax: an international journal of respiratory medicine, 70 12: 1199-1201. doi:10.1136/thoraxjnl-2014-206736

Author Kim. Richard Y.
Pinkerton, James W.
Gibson, Peter G.
Cooper, Matthew A.
Horvat, Jay C.
Hansbro, Philip M.
Title Inflammasomes in COPD and neutrophilic asthma
Journal name Thorax: an international journal of respiratory medicine   Check publisher's open access policy
ISSN 0040-6376
Publication date 2015-10-22
Year available 2015
Sub-type Article (original research)
DOI 10.1136/thoraxjnl-2014-206736
Open Access Status Not Open Access
Volume 70
Issue 12
Start page 1199
End page 1201
Total pages 3
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Subject 2740 Pulmonary and Respiratory Medicine
Abstract Inflammasomes have recently been identified to be critical and potent inducers of inflammation that when overactive may be targeted therapeutically in inflammatory diseases. Inflammasomes are multiprotein signalling complexes that control the maturation and release of pro-inflammatory cytokines in response to numerous exogenous, endogenous and pathogenic danger signals (figure 1).1 They mediate host responses, particularly interleukin (IL)-1β release and neutrophilic inflammatory responses, which are essential for protection against infection. However, recent evidence demonstrates that excessive inflammasome activation is a feature of numerous inflammatory diseases including COPD, neutrophilic asthma, idiopathic pulmonary fibrosis, cystic fibrosis, acute respiratory distress syndrome (ARDS) and respiratory infections (table in figure 1). Infections are the most widely recognised activators of inflammasomes; however, this field has recently been reviewed extensively and is beyond the scope of this article. Their roles in ARDS and potential for therapeutic targeting are well established.2 It is now emerging that inflammasomes are likely involved in the pathogenesis of COPD and asthma, and further investigation is urgently needed.
Keyword Respiratory System
Respiratory System
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 09 Dec 2015, 19:10:22 EST by Susan Allen on behalf of Institute for Molecular Bioscience