Recognition of Vitamin B precursors and byproducts by Mucosal Associated Invariant T cells

Eckle, Sidonia B.G., Corbett, Alexandra J., Keller, Andrew, Chen, Zhenjun, Godfrey, Dale I., Liu, Ligong, Mak, Jeffrey Y. W., Fairlie, David P., Rossjohn, Jamie and McCluskey, James (2015) Recognition of Vitamin B precursors and byproducts by Mucosal Associated Invariant T cells. The Journal of Biological Chemistry, 290 51: 30204-30211. doi:10.1074/jbc.R115.685990

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Author Eckle, Sidonia B.G.
Corbett, Alexandra J.
Keller, Andrew
Chen, Zhenjun
Godfrey, Dale I.
Liu, Ligong
Mak, Jeffrey Y. W.
Fairlie, David P.
Rossjohn, Jamie
McCluskey, James
Title Recognition of Vitamin B precursors and byproducts by Mucosal Associated Invariant T cells
Journal name The Journal of Biological Chemistry   Check publisher's open access policy
ISSN 0021-9258
Publication date 2015-12-18
Year available 2015
Sub-type Article (original research)
DOI 10.1074/jbc.R115.685990
Open Access Status File (Publisher version)
Volume 290
Issue 51
Start page 30204
End page 30211
Total pages 16
Place of publication Bethesda, MD, United States
Publisher American Society for Biochemistry and Molecular Biology
Language eng
Abstract Vitamin B2 (riboflavin) is essential for metabolic functions and is synthesized by many bacteria, yeast and plants, but not by mammals and other animals, which must acquire it from the diet. In mammals, modified pyrimidine intermediates from the microbial biosynthesis of riboflavin are recognized as signature biomarkers of microbial infection. This recognition occurs by specialized lymphocytes known as Mucosal Associated Invariant T (MAIT) cells. The Major Histocompatibility class I-like antigen presenting molecule, MR1, captures these pyrimidine intermediates, but only after their condensation with small molecules derived from glycolysis and other metabolic pathways to form short-lived antigens. The resulting MR1-Ag complexes are recognized by MAIT cell antigen receptors (αβ TCRs) and the subsequent MAIT cell immune responses are thought to protect the host from pathogens at mucosal surfaces. Here we review our understanding of how these novel antigens are generated and discuss their interactions with MR1 and MAIT TCRs.
Keyword Biochemistry & Molecular Biology
Biochemistry & Molecular Biology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID E140100011
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
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Created: Wed, 09 Dec 2015, 01:49:37 EST by Susan Allen on behalf of Institute for Molecular Bioscience