An unusual recurrence of adenosquamous carcinoma of the lung

Pokharel, Khageshwor, Godbolt, David and Hughes, Brett G. M. (2015) An unusual recurrence of adenosquamous carcinoma of the lung. Cancer Treatment Communications, 4 37-40. doi:10.1016/j.ctrc.2015.03.006

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Author Pokharel, Khageshwor
Godbolt, David
Hughes, Brett G. M.
Title An unusual recurrence of adenosquamous carcinoma of the lung
Journal name Cancer Treatment Communications   Check publisher's open access policy
ISSN 2213-0896
Publication date 2015-01-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.ctrc.2015.03.006
Open Access Status Not Open Access
Volume 4
Start page 37
End page 40
Total pages 4
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 2730 Oncology
Abstract Adenosquamous carcinoma of the lung is an uncommon histological variant of non-small cell lung carcinoma (NSCLC) associated with a poorer prognosis than either adenocarcinoma or squamous cell carcinoma (SCC) histological subtypes. Most adenosquamous carcinomas of the lung present with advanced disease, often with the central nervous system as a common site of metastasis. We present a case of a patient with recurrent adenosquamous carcinoma who presents with multiple cerebral metastases, with two metastatic sites composed of separate distinct histological subtypes, one adenocarcinoma and one SCC. Interestingly, both metastatic deposits were also found to harbor an L858R epithelial growth factor receptor (EGFR) point mutation in exon 21. Upon progression after craniotomy and whole brain radiotherapy, the patient achieved a radiological response with the EGFR inhibitor, erlotinib.
Keyword Non-small cell lung cancer
EGFR mutation
Histology discordance
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
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Created: Tue, 08 Dec 2015, 13:03:44 EST by System User on behalf of School of Medicine