Cardiorespiratory fitness, sedentary time, and cardiovascular risk factor clustering

Nauman, Javaid, Stensvold, Dorthe, Coombes, Jeff S. and Wisloff, Ulrik (2016) Cardiorespiratory fitness, sedentary time, and cardiovascular risk factor clustering. Medicine and Science in Sports and Exercise, 48 4: 1-36. doi:10.1249/MSS.0000000000000819

Author Nauman, Javaid
Stensvold, Dorthe
Coombes, Jeff S.
Wisloff, Ulrik
Title Cardiorespiratory fitness, sedentary time, and cardiovascular risk factor clustering
Journal name Medicine and Science in Sports and Exercise   Check publisher's open access policy
ISSN 1530-0315
Publication date 2016-04-01
Year available 2015
Sub-type Article (original research)
DOI 10.1249/MSS.0000000000000819
Open Access Status Not Open Access
Volume 48
Issue 4
Start page 1
End page 36
Total pages 36
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams and Wilkins
Language eng
Formatted abstract
Purpose: Prolonged sedentary time (ST) is associated with cardiovascular risk factors (CV-RF) independent of physical activity (PA). Whether a high level of cardiorespiratory fitness (CRF) can modify the deleterious health consequences related to high ST is not known.

Methods: Cross-sectional study of 12274 men and 14209 women (>=20 years) without known cardiovascular disease. Self-reported ST measurements during a regular day were divided into three sex specific equally sized groups (<=4, 5-<7, and >=7h/day). CRF was estimated (eCRF) using a previously validated non-exercise model. Using logistic regression analyses, adjusted odds ratios and 95% confidence intervals (OR (95% CI)) were estimated for the association of ST with CV-RF clustering, and for the potential modifying effect of eCRF.

Results: Each hour increase in ST was associated with 5% and 4% greater likelihood of having a CV-RF clustering independent of PA in men and women, respectively. Among participants with higher levels of eCRF, the adjusted ORs associated with >=7h/day of ST were 0.92 (0.56-1.51) for men, and 1.16 (0.49-2.74) for women, compared with the men and women with low ST (<=4h/day) and high eCRF levels. In combined analyses of eCRF, PA and ST, compared with the reference group of participants meeting the recommendations, <=4h/day of ST and high eCRF, the ORs were 0.63 (0.27-1.44) and 0.65 (0.14-3.07) in fit men and women with >=7h/day of ST, and not meeting the recommendations. Men and women meeting the PA recommendations, but being unfit had significantly increased odds of having CV-RF clustering across levels of ST.

Conclusion: High levels of eCRF abolished the increased odds of having a clustering of CV-RF associated with high ST, even among those individuals who did not meet current PA recommendations.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Human Movement and Nutrition Sciences Publications
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