The impact of peripheral nerve stimulation on coronary blood flow and endothelial function

Camuglia, Anthony C., Alemayehu, Mistre, McLellan, Andrew, Wall, Sabrina, Abu-Romeh, Nour and Lavi, Shahar (2015) The impact of peripheral nerve stimulation on coronary blood flow and endothelial function. Cardiovascular Drugs and Therapy, 29 6: 527-533. doi:10.1007/s10557-015-6628-z

Author Camuglia, Anthony C.
Alemayehu, Mistre
McLellan, Andrew
Wall, Sabrina
Abu-Romeh, Nour
Lavi, Shahar
Title The impact of peripheral nerve stimulation on coronary blood flow and endothelial function
Journal name Cardiovascular Drugs and Therapy   Check publisher's open access policy
ISSN 1573-7241
Publication date 2015-11-23
Sub-type Article (original research)
DOI 10.1007/s10557-015-6628-z
Open Access Status Not Open Access
Volume 29
Issue 6
Start page 527
End page 533
Total pages 7
Place of publication New York, NY, United States
Publisher Springer New York
Language eng
Formatted abstract
Purpose: The geko™ device is a small transcutaneous nerve stimulator that is applied non-invasively to the skin over the common peroneal nerve to stimulate peripheral blood flow. The purpose of this study was to investigate the effect of peripheral nerve stimulation on coronary flow dynamics and systemic endothelial function.

Methods: We enrolled 10 male patients, age 59 ± 11 years, with symptomatic obstructive coronary disease undergoing percutaneous coronary intervention (PCI). Coronary flow dynamics were assessed invasively using Doppler flow wire at baseline and with nerve stimulation for 4 min. Measurements were taken in the stenotic coronary artery and in a control vessel without obstructive disease. At a separate visit, peripheral blood flow at the popliteal artery (using duplex ultrasound assessment) and endothelial function assessed by peripheral artery tonometry (PAT) were measured at baseline and after one hour of nerve stimulation.

Results: Compared to baseline, there was a significant increase in coronary blood flow as measured by average peak velocity (APV) in the control vessel with nerve stimulation (20.3 ± 7.7 to 23.5 ± 10 cm/s; p = 0.03) and non-significant increase in the stenotic vessel (21.9 ± 12 to 23.9 ± 12.9 cm/s; p = 0.23). Coronary flow reserve did not change significantly. Reactive hyperemia-peripheral arterial tonometry (Rh-PAT) increased from 2.28 ± 0.39 to 2.67 ± 0.6, p = 0.045.

Conclusions: A few minutes of peripheral nerve stimulation may improve coronary blood flow. This effect is more prominent in non-stenotic vessels. Longer stimulation improved endothelial function.
Keyword Angina
Blood flow
Coronary artery disease
Electrical stimulation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
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