The maturation of mismatch negativity networks in normal adolescence

Cooray, G. K., Garrido, M. I., Brismar, T. and Hyllienmark, L. (2016) The maturation of mismatch negativity networks in normal adolescence. Clinical Neurophysiology, 127 1: 520-529. doi:10.1016/j.clinph.2015.06.026

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Author Cooray, G. K.
Garrido, M. I.
Brismar, T.
Hyllienmark, L.
Title The maturation of mismatch negativity networks in normal adolescence
Journal name Clinical Neurophysiology   Check publisher's open access policy
ISSN 1388-2457
Publication date 2016-01-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.clinph.2015.06.026
Open Access Status File (Author Post-print)
Volume 127
Issue 1
Start page 520
End page 529
Total pages 10
Place of publication Shannon, Clare Ireland
Publisher Elsevier
Language eng
Formatted abstract
Objective: We investigated the neurophysiological mechanisms underpinning the generation of the mismatch negativity (MMN) and its development from adolescence to early adulthood.

Methods: We used dynamic causal modelling (DCM) to study connectivity models for healthy adults and adolescents. MMN was elicited with an auditory oddball paradigm in two groups of healthy subjects with mean age 14 (n = 52) and 26 (n = 26). We tested models with different hierarchical complexities including up to five cortical nodes.

Results: We showed that the network generating MMN consisted of 5 nodes that could modulate all intra- and internodal connections. The inversion of this model showed that adolescents had reduced backward connection from rIFG to rSTG (p < 0.04) together with increased excitatory activity in rSTG (p < 0.02). There was a reduced modulation of excitability in rSTG (p < 0.02) and of forward connectivity from lA1 to lSTG (p < 0.03).

Conclusion: The cortical network generating MMN continues to develop in adolescence up to adulthood. Cortical regions in the temporal and frontal lobes, involved in auditory processing, mature with increasing fronto-temporal connectivity together with increased sensitivity in the temporal regions for changes in sound stimuli.

Significance: This study may offer an explanation for the neurobiological maturation of the MMN in adolescence.
Keyword Mismatch negativity
Dynamic casual modelling
Maturation adolescence
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
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Created: Tue, 08 Dec 2015, 02:06:47 EST by Susan Day on behalf of Queensland Brain Institute