Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease

Persson, Jonas, Strawbridge, Rona J., McLeod, Olga, Gertow, Karl, Silveira, Angela, Baldassarre, Damiano, Van Zuydam, Natalie, Shah, Sonia, Fava, Cristiano, Gustafsson, Stefan, Veglia, Fabrizio, Sennblad, Bengt, Larsson, Malin, Sabater-Lleal, Maria, Leander, Karin, Gigante, Bruna, Tabak, Adam, Kivimaki, Mika, Kauhanen, Jussi, Rauramaa, Rainer, Smit, Andries J., Mannarino, Elmo, Giral, Philippe, Humphries, Steve E., Tremoli, Elena, de Faire, Ulf, Lind, Lars, Ingelsson, Erik, Hedblad, Bo, Melander, Olle, Kumari, Meena, Hingorani, Aroon, Morris, Andrew D., Palmer, Colin N. A., Lundman, Pia, Ohrvik, John and Soderberg, Stefan (2015) Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease. Journal of the American Heart Association, 4 8: 1-13. doi:10.1161/JAHA.115.001853

Author Persson, Jonas
Strawbridge, Rona J.
McLeod, Olga
Gertow, Karl
Silveira, Angela
Baldassarre, Damiano
Van Zuydam, Natalie
Shah, Sonia
Fava, Cristiano
Gustafsson, Stefan
Veglia, Fabrizio
Sennblad, Bengt
Larsson, Malin
Sabater-Lleal, Maria
Leander, Karin
Gigante, Bruna
Tabak, Adam
Kivimaki, Mika
Kauhanen, Jussi
Rauramaa, Rainer
Smit, Andries J.
Mannarino, Elmo
Giral, Philippe
Humphries, Steve E.
Tremoli, Elena
de Faire, Ulf
Lind, Lars
Ingelsson, Erik
Hedblad, Bo
Melander, Olle
Kumari, Meena
Hingorani, Aroon
Morris, Andrew D.
Palmer, Colin N. A.
Lundman, Pia
Ohrvik, John
Soderberg, Stefan
Title Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease
Journal name Journal of the American Heart Association   Check publisher's open access policy
ISSN 2047-9980
Publication date 2015-08-01
Sub-type Article (original research)
DOI 10.1161/JAHA.115.001853
Open Access Status DOI
Volume 4
Issue 8
Start page 1
End page 13
Total pages 13
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Background: Plasma adiponectin levels have previously been inversely associated with carotid intima‐media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex‐stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT.

Methods and Results: Baseline plasma adiponectin concentration was tested for association with baseline IMT, IMT progression over 30 months, and occurrence of cardiovascular events within 3 years in 3430 participants (women, n=1777; men, n=1653) with high cardiovascular risk but no prevalent disease. Plasma adiponectin levels were inversely associated with baseline mean bifurcation IMT after adjustment for established risk factors (β=−0.018, P<0.001) in men but not in women (β=−0.006, P=0.185; P for interaction=0.061). Adiponectin levels were inversely associated with progression of mean common carotid IMT in men (β=−0.0022, P=0.047), whereas no association was seen in women (0.0007, P=0.475; P for interaction=0.018). Moreover, we observed that adiponectin levels were inversely associated with coronary events in women (hazard ratio 0.57, 95% CI 0.37 to 0.87) but not in men (hazard ratio 0.82, 95% CI 0.54 to 1.25). A gene score of adiponectin‐raising alleles in 6 loci, reported recently in a large multi‐ethnic meta‐analysis, was inversely associated with baseline mean bifurcation IMT in men (β=−0.0008, P=0.004) but not in women (β=−0.0003, P=0.522; P for interaction=0.007).

Conclusions: This report provides some evidence for adiponectin protecting against atherosclerosis, with effects being confined to men; however, compared with established cardiovascular risk factors, the effect of plasma adiponectin was modest. Further investigation involving mechanistic studies is warranted.
Keyword Adiponectin
Carotid intima-media thickness
Mendelian randomization
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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