Lung function and exhaled nitric oxide in healthy unsedated African infants

Gray, Diane, Willemse, Lauren, Visagie, Ane, Smith, Emilee, Czoevek, Dorottya, Sly, Peter D., Hantos, Zoltan, Hall, Graham L. and Zar, Heather J. (2015) Lung function and exhaled nitric oxide in healthy unsedated African infants. Respirology, 20 7: 1108-1114. doi:10.1111/resp.12579


Author Gray, Diane
Willemse, Lauren
Visagie, Ane
Smith, Emilee
Czoevek, Dorottya
Sly, Peter D.
Hantos, Zoltan
Hall, Graham L.
Zar, Heather J.
Title Lung function and exhaled nitric oxide in healthy unsedated African infants
Journal name Respirology   Check publisher's open access policy
ISSN 1440-1843
1323-7799
Publication date 2015-10-01
Year available 2015
Sub-type Article (original research)
DOI 10.1111/resp.12579
Open Access Status DOI
Volume 20
Issue 7
Start page 1108
End page 1114
Total pages 7
Place of publication Richmond, VIC Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Formatted abstract
Background and objective
Population-appropriate lung function reference data are essential to accurately identify respiratory disease and measure response to interventions. There are currently no reference data in African infants. The aim was to describe normal lung function in healthy African infants.

Methods
Lung function was performed on healthy South African infants enrolled in a birth cohort study, the Drakenstein child health study. Infants were excluded if they were born preterm or had a history of neonatal respiratory distress or prior respiratory tract infection. Measurements, made during natural sleep, included the forced oscillation technique, tidal breathing, exhaled nitric oxide and multiple breath washout measures.

Results
Three hundred sixty-three infants were tested. Acceptable and repeatable measurements were obtained in 356 (98%) and 352 (97%) infants for tidal breathing analysis and exhaled nitric oxide outcomes, 345 (95%) infants for multiple breath washout and 293 of the 333 (88%) infants for the forced oscillation technique. Age, sex and weight-for-age z score were significantly associated with lung function measures.

Conclusions
This study provides reference data for unsedated infant lung function in African infants and highlights the importance of using population-specific data.
Keyword African
Infants
Lung function
Reference data
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Child Health Research Centre Publications
 
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