Frontal dynamic aphasia in progressive supranuclear palsy: distinguishing between generation and fluent sequencing of novel thoughts

Robinson, Gail A., Spooner, Donna and Harrison, William J. (2015) Frontal dynamic aphasia in progressive supranuclear palsy: distinguishing between generation and fluent sequencing of novel thoughts. Neuropsychologia, 77 62-75. doi:10.1016/j.neuropsychologia.2015.08.001

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Author Robinson, Gail A.
Spooner, Donna
Harrison, William J.
Title Frontal dynamic aphasia in progressive supranuclear palsy: distinguishing between generation and fluent sequencing of novel thoughts
Journal name Neuropsychologia   Check publisher's open access policy
ISSN 1873-3514
0028-3932
Publication date 2015-10-01
Sub-type Article (original research)
DOI 10.1016/j.neuropsychologia.2015.08.001
Open Access Status File (Author Post-print)
Volume 77
Start page 62
End page 75
Total pages 14
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Formatted abstract
Frontal dynamic aphasia is characterised by a profound reduction in spontaneous speech despite well-preserved naming, repetition and comprehension. Since Luria, 1966 and Luria, 1970 designated this term, two main forms of dynamic aphasia have been identified: one, a language-specific selection deficit at the level of word/sentence generation, associated with left inferior frontal lesions; and two, a domain-general impairment in generating multiple responses or connected speech, associated with more extensive bilateral frontal and/or frontostriatal damage. Both forms of dynamic aphasia have been interpreted as arising due to disturbances in early prelinguistic conceptual preparation mechanisms that are critical for language production. We investigate language-specific and domain-general accounts of dynamic aphasia and address two issues: one, whether deficits in multiple conceptual preparation mechanisms can co-occur; and two, the contribution of broader cognitive processes such as energization, the ability to initiate and sustain response generation over time, to language generation failure. Thus, we report patient WAL who presented with frontal dynamic aphasia in the context of progressive supranuclear palsy (PSP). WAL was given a series of experimental tests that showed that his dynamic aphasia was not underpinned by a language-specific deficit in selection or in microplanning. By contrast, WAL presented with a domain-general deficit in fluent sequencing of novel thoughts. The latter replicated the pattern documented in a previous PSP patient ( Robinson, et al., 2006); however, unique to WAL, generating novel thoughts was impaired but there was no evidence of a sequencing deficit because perseveration was absent. Thus, WAL is the first unequivocal case to show a distinction between novel thought generation and subsequent fluent sequencing. Moreover, WAL's generation deficit encompassed verbal and non-verbal responses, showing a similar (but more profoundly reduced) pattern of performance to frontal patients with an energization deficit. In addition to impaired generation of novel thoughts, WAL presented with a concurrent strategy generation deficit, both falling within the second form of dynamic aphasia comprised of domain-general conceptual preparation mechanisms. Thus, within this second form of dynamic aphasia, concurrent deficits can co-occur. Overall, WAL presented with the second form of dynamic aphasia and was impaired in the generation of novel thoughts and internally-generated strategies, in the context of PSP and bilateral frontostriatal damage.
Keyword Conceptual preparation
Dynamic aphasia
Energization
Non-fluent aphasia
Novel thought generation
Progressive supranuclear palsy
Strategy generation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
School of Psychology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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