Efficacy of the Omega-3 Index in predicting NAFLD in overweight and obese adults: a pilot study

Parker, Helen M., O'Connor, Helen T., Keating, Shelley E., Cohn, Jeffrey S., Garg, Manohar L., Caterson, Ian D., George, Jacob and Johnson, Nathan A. (2015) Efficacy of the Omega-3 Index in predicting NAFLD in overweight and obese adults: a pilot study. British Journal of Nutrition, 114 5: 780-787. doi:10.1017/S0007114515002305

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ374693_OA.pdf application/pdf 312.72KB 0

Author Parker, Helen M.
O'Connor, Helen T.
Keating, Shelley E.
Cohn, Jeffrey S.
Garg, Manohar L.
Caterson, Ian D.
George, Jacob
Johnson, Nathan A.
Title Efficacy of the Omega-3 Index in predicting NAFLD in overweight and obese adults: a pilot study
Journal name British Journal of Nutrition   Check publisher's open access policy
ISSN 0007-1145
Publication date 2015-01-01
Year available 2015
Sub-type Article (original research)
DOI 10.1017/S0007114515002305
Open Access Status File (Publisher version)
Volume 114
Issue 5
Start page 780
End page 787
Total pages 8
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Language eng
Abstract Non-alcoholic fatty liver disease (NAFLD) is an independent predictor of CVD in otherwise healthy individuals. Low n-3 PUFA intake has been associated with the presence of NAFLD; however, the relationship between a biomarker of n-3 status - the Omega-3 Index - and liver fat is yet to be elucidated. A total of eighty overweight adults (fifty-six men) completed the anthropometric and biochemical measurements, including the Omega-3 Index, and underwent proton magnetic resonance spectroscopy assessment of liver fat. Bivariate correlations and multiple regression analyses were performed with reference to prediction of liver fat percentage. The mean Omega-3 Index was high in both NAFLD (intrahepatic lipid concentration≥5·5 %) and non-NAFLD groups. The Omega-3 Index, BMI, waist circumference, glucose, insulin, TAG, high-sensitive C-reactive protein (hsCRP) and alanine aminotransferase (ALT) were positively correlated, and HDL and erythrocyte n-6:n-3 ratio negatively correlated with liver fat concentration. Regression analysis found that simple anthropometric and demographic variables (waist, age) accounted for 31 % of the variance in liver fat and the addition of traditional cardiometabolic blood markers (TAG, HDL, hsCRP and ALT) increased the predictive power to 43 %. The addition of the novel erythrocyte fatty acid variable (Omega-3 Index) to the model only accounted for a further 3 % of the variance (P=0·049). In conclusion, the Omega-3 Index was associated with liver fat concentration but did not improve the overall capacity of demographic, anthropometric and blood markers to predict NAFLD.
Keyword Nonalcoholic fatty liver disease
n-3 PUFA
Omega-3 index
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1053206
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Human Movement and Nutrition Sciences Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 04 Dec 2015, 01:13:19 EST by Shelley Keating on behalf of School of Human Movement and Nutrition Sciences