Towards a dynamic understanding of cadherin-based mechanobiology

Hoffman, Brenton D. and Yap, Alpha S. (2015) Towards a dynamic understanding of cadherin-based mechanobiology. Trends in Cell Biology, 25 12: 803-814. doi:10.1016/j.tcb.2015.09.008

Author Hoffman, Brenton D.
Yap, Alpha S.
Title Towards a dynamic understanding of cadherin-based mechanobiology
Journal name Trends in Cell Biology   Check publisher's open access policy
ISSN 0962-8924
Publication date 2015-12-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.tcb.2015.09.008
Open Access Status Not Open Access
Volume 25
Issue 12
Start page 803
End page 814
Total pages 12
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Language eng
Subject 1307 Cell Biology
Abstract Cadherin-based cell-cell adhesions are a primary determinant of tissue structure. For several decades, it had been thought that the primary function of these ubiquitous structures was to resist external mechanical loads. Here we review recent evidence that cadherins also couple together the force-generating actomyosin cytoskeletons of neighbouring cells, serve as potent regulators of the actomyosin cytoskeleton, and activate diverse signalling pathways in response to applied load. In considering the force sensitivity of the molecular-scale processes that mediate these events, we propose a dynamic picture of the force-sensitive processes in cell-cell contacts. This quantitative and physical understanding of the mechanobiology of cadherin cell-cell junctions will aid endeavours to study the fundamental processes mediating the development and maintenance of tissue structure.
Keyword Cell Biology
Cell Biology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1044041
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 25 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 28 times in Scopus Article | Citations
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Created: Thu, 03 Dec 2015, 19:01:56 EST by Susan Allen on behalf of Institute for Molecular Bioscience