Association of human papillomavirus with Fanconi anemia promotes carcinogenesis in Fanconi anemia patients

Liu, Guang Bin, Chen, Jiezhong, Wu, Zhan He and Zhao, Kong-Nan (2015) Association of human papillomavirus with Fanconi anemia promotes carcinogenesis in Fanconi anemia patients. Reviews in Medical Virology, 25 6: 345-353. doi:10.1002/rmv.1834


Author Liu, Guang Bin
Chen, Jiezhong
Wu, Zhan He
Zhao, Kong-Nan
Title Association of human papillomavirus with Fanconi anemia promotes carcinogenesis in Fanconi anemia patients
Journal name Reviews in Medical Virology   Check publisher's open access policy
ISSN 1099-1654
1052-9276
Publication date 2015-11-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/rmv.1834
Open Access Status Not Open Access
Volume 25
Issue 6
Start page 345
End page 353
Total pages 9
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley and Sons
Language eng
Subject 2406 Virology
2725 Infectious Diseases
Abstract Fanconi anemia (FA) is a rare recessive disorder associated with chromosomal fragility. FA patients are at very high risk of cancers, especially head and neck squamous cell carcinomas and squamous cell carcinomas caused by infection of human papillomaviruses (HPVs). By integrating into the host genome, HPV oncogenes E6 and E7 drive the genomic instability to promote DNA damage and gene mutations necessary for carcinogenesis in FA patients. Furthermore, E6 and E7 oncoproteins not only inhibit p53 and retinoblastoma but also impair the FANC/BRCA signaling pathway to prevent DNA damage repair and alter multiple signals including cell-cycle checkpoints, telomere function, cell proliferation, and interference of the host immune system leading to cancer development in FA patients. In this review, we summarize recent advances in unraveling the molecular mechanisms of FA susceptibility to HPV-induced cancers, which facilitate rational preventive and therapeutic strategies.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
School of Medicine Publications
 
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