Supercritical fluid technologies to fabricate proliposomes

Falconer, James R., Svirskis, Darren, Adil, Ali A. and Wu, Zimei (2015) Supercritical fluid technologies to fabricate proliposomes. Journal of Pharmacy and Pharmaceutical Sciences, 18 5: 747-764.

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Author Falconer, James R.
Svirskis, Darren
Adil, Ali A.
Wu, Zimei
Title Supercritical fluid technologies to fabricate proliposomes
Journal name Journal of Pharmacy and Pharmaceutical Sciences   Check publisher's open access policy
ISSN 1482-1826
Publication date 2015-11-10
Sub-type Critical review of research, literature review, critical commentary
Open Access Status File (Publisher version)
Volume 18
Issue 5
Start page 747
End page 764
Total pages 18
Place of publication Edmonton, AB, Canada
Publisher Canadian Society for Pharmaceutical Sciences
Language eng
Abstract Proliposomes are stable drug carrier systems designed to form liposomes upon addition of an aqueous phase. In this review, current trends in the use of supercritical fluid (SCF) technologies to prepare proliposomes are discussed. SCF methods are used in pharmaceutical research and industry to address limitations associated with conventional methods of pro/liposome fabrication. The SCF solvent methods of proliposome preparation are eco-friendly (known as green technology) and, along with the SCF anti-solvent methods, could be advantageous over conventional methods; enabling better design of particle morphology (size and shape). The major hurdles of SCF methods include poor scalability to industrial manufacturing which may result in variable particle characteristics. In the case of SCF anti-solvent methods, another hurdle is the reliance on organic solvents. However, the amount of solvent required is typically less than that used by the conventional methods. Another hurdle is that most of the SCF methods used have complicated manufacturing processes, although once the setup has been completed, SCF technologies offer a single-step process in the preparation of proliposomes compared to the multiple steps required by many other methods. Furthermore, there is limited research into how proliposomes will be converted into liposomes for the end-user, and how such a product can be prepared reproducibly in terms of vesicle size and drug loading. These hurdles must be overcome and with more research, SCF methods, especially where the SCF acts as a solvent, have the potential to offer a strong alternative to the conventional methods to prepare proliposomes.
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Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Pharmacy Publications
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