Paracingulate sulcus morphology is associated with hallucinations in the human brain

Garrison, Jane R., Fernyhough, Charles, McCarthy-Jones, Simon, Haggard, Mark, The Australian Schizophrenia Research Bank, Carr, Vaughan, Schall, Ulrich, Scott, Rodney, Jablensky, Assen, Mowry, Bryan, Michie, Patricia, Catts, Stanley, Henskens, Frans, Pantelis, Christos, Loughland, Carmel and Simons, Jon S. (2015) Paracingulate sulcus morphology is associated with hallucinations in the human brain. Nature Communications, 6 8956.1-8956.6. doi:10.1038/ncomms9956

Author Garrison, Jane R.
Fernyhough, Charles
McCarthy-Jones, Simon
Haggard, Mark
The Australian Schizophrenia Research Bank
Carr, Vaughan
Schall, Ulrich
Scott, Rodney
Jablensky, Assen
Mowry, Bryan
Michie, Patricia
Catts, Stanley
Henskens, Frans
Pantelis, Christos
Loughland, Carmel
Simons, Jon S.
Title Paracingulate sulcus morphology is associated with hallucinations in the human brain
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2015-11-17
Sub-type Article (original research)
DOI 10.1038/ncomms9956
Open Access Status DOI
Volume 6
Start page 8956.1
End page 8956.6
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1600 Chemistry
1300 Biochemistry, Genetics and Molecular Biology
3100 Physics and Astronomy
Abstract Hallucinations are common in psychiatric disorders, and are also experienced by many individuals who are not mentally ill. Here, in 153 participants, we investigate brain structural markers that predict the occurrence of hallucinations by comparing patients with schizophrenia who have experienced hallucinations against patients who have not, matched on a number of demographic and clinical variables. Using both newly validated visual classification techniques and automated, data-driven methods, hallucinations were associated with specific brain morphology differences in the paracingulate sulcus, a fold in the medial prefrontal cortex, with a 1 cm reduction in sulcal length increasing the likelihood of hallucinations by 19.9%, regardless of the sensory modality in which they were experienced. The findings suggest a specific morphological basis for a pervasive feature of typical and atypical human experience.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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