Chelator-free labeling of layered double hydroxide nanoparticles for in vivo PET imaging

Shi, Sixiang, Fliss, Brianne C., Gu, Zi, Zhu, Yian, Hong, Hao, Valdovinos, Hector F., Hernandez, Reinier, Goel, Shreya, Luo, Haiming, Chen, Feng, Barnhart, Todd E., Nickles, Robert J., Xu, Zhi Ping and Cai, Weibo (2015) Chelator-free labeling of layered double hydroxide nanoparticles for in vivo PET imaging. Scientific Reports, 5 . doi:10.1038/srep16930


Author Shi, Sixiang
Fliss, Brianne C.
Gu, Zi
Zhu, Yian
Hong, Hao
Valdovinos, Hector F.
Hernandez, Reinier
Goel, Shreya
Luo, Haiming
Chen, Feng
Barnhart, Todd E.
Nickles, Robert J.
Xu, Zhi Ping
Cai, Weibo
Title Chelator-free labeling of layered double hydroxide nanoparticles for in vivo PET imaging
Formatted title
Chelator-free labeling of layered double hydroxide nanoparticles for in vivo PET imaging
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2015-11-20
Sub-type Article (original research)
DOI 10.1038/srep16930
Open Access Status DOI
Volume 5
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
Layered double hydroxide (LDH) nanomaterial has emerged as a novel delivery agent for biomedical applications due to its unique structure and properties. However, in vivo positron emission tomography (PET) imaging with LDH nanoparticles has not been achieved. The aim of this study is to explore chelator-free labeling of LDH nanoparticles with radioisotopes for in vivo PET imaging. Bivalent cation 64Cu2+ and trivalent cation 44Sc3+ were found to readily label LDH nanoparticles with excellent labeling efficiency and stability, whereas tetravalent cation 89Zr4+ could not label LDH since it does not fit into the LDH crystal structure. PET imaging shows that prominent tumor uptake was achieved in 4T1 breast cancer with 64Cu-LDH-BSA via passive targeting alone (7.7 ± 0.1%ID/g at 16 h post-injection; n = 3). These results support that LDH is a versatile platform that can be labeled with various bivalent and trivalent radiometals without comprising the native properties, highly desirable for PET image-guided drug delivery.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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