A comparison of vitamin D activity in paired non-malignant and malignant human breast tissues

Suetani, Rachel J., Ho, Kristen, Jindal, Shalini, Manavis, Jim, Neilsen, Paul M., Pishas, Kathleen I., Rippy, Elisabeth, Bochner, Melissa, Kollias, James, Gill, P. Grantley, Morris, Howard A. and Callen, David F. (2012) A comparison of vitamin D activity in paired non-malignant and malignant human breast tissues. Molecular and Cellular Endocrinology, 362 1-2: 202-210. doi:10.1016/j.mce.2012.06.022

Author Suetani, Rachel J.
Ho, Kristen
Jindal, Shalini
Manavis, Jim
Neilsen, Paul M.
Pishas, Kathleen I.
Rippy, Elisabeth
Bochner, Melissa
Kollias, James
Gill, P. Grantley
Morris, Howard A.
Callen, David F.
Title A comparison of vitamin D activity in paired non-malignant and malignant human breast tissues
Journal name Molecular and Cellular Endocrinology   Check publisher's open access policy
ISSN 0303-7207
Publication date 2012-10-01
Sub-type Article (original research)
DOI 10.1016/j.mce.2012.06.022
Open Access Status Not Open Access
Volume 362
Issue 1-2
Start page 202
End page 210
Total pages 9
Place of publication Shannon, Clare, Ireland
Publisher Elsevier
Language eng
Formatted abstract
Links between a low vitamin D status and an increased risk of breast cancer have been observed in epidemiological studies. These links have been investigated in human tissue homogenates and cultured cell lines. We have used non-malignant, malignant and normal reduction mammoplasty breast tissues to investigate the biological and metabolic consequences of the application of vitamin D to intact ex vivo human breast tissue. Tissues were exposed to 1α,25(OH)2D3 (1,25D; active metabolite) and 25(OH)D (25D; pre-metabolite). Changes in mRNA expression and protein expression after vitamin D exposure were analysed. Results indicate that while responses in normal and non-malignant breast tissues are similar between individuals, different tumour tissues are highly variable with regards to their gene expression and biological response. Collectively, malignant breast tissue responds well to active 1,25D, but not to the inactive pre-metabolite 25D. This may have consequences for the recommendation of vitamin D supplementation in breast cancer patients.
Keyword 1,25-Dihydroxyvitamin D
25-Hydroxyvitamin D
Breast cancer
Ex vivo breast tissue
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Created: Mon, 30 Nov 2015, 19:40:18 EST by Rachel Suetani on behalf of Queensland Brain Institute