The oncogenic role of miR-155 in breast cancer

Mattiske, Sam, Suetani, Rachel J., Neilsen, Paul M. and Callen, David F. (2012) The oncogenic role of miR-155 in breast cancer. Cancer Epidemiology, Biomarkers and Prevention, 21 8: 1236-1243. doi:10.1158/1055-9965.EPI-12-0173

Author Mattiske, Sam
Suetani, Rachel J.
Neilsen, Paul M.
Callen, David F.
Title The oncogenic role of miR-155 in breast cancer
Journal name Cancer Epidemiology, Biomarkers and Prevention   Check publisher's open access policy
ISSN 1055-9965
Publication date 2012-08-21
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1158/1055-9965.EPI-12-0173
Open Access Status Not yet assessed
Volume 21
Issue 8
Start page 1236
End page 1243
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher American Association for Cancer Research
Language eng
Abstract miR-155 is an oncogenic miRNA with well described roles in leukemia. However, additional roles of miR-155 in breast cancer progression have recently been described. A thorough literature search was conducted to review all published data to date, examining the role of miR-155 in breast cancer. Data on all validated miR-155 target genes was collated to identify biologic pathways relevant to miR-155 and breast cancer progression. Publications describing the clinical relevance, functional characterization, and regulation of expression of miR-155 in the context of breast cancer are reviewed. A total of 147 validated miR- 155 target genes were identified from the literature. Pathway analysis of these genes identified likely roles in apoptosis, differentiation, angiogenesis, proliferation, and epithelial-mesenchymal transition. The large number of validated miR-155 targets presented here provide many avenues of interest as to the clinical potential of miR-155. Further investigation of these target genes will be required to elucidate the specific mechanisms and functions of miR-155 in breast cancer. This is the first review examining the role of miR- 155 in breast cancer progression. The collated data of target genes and biologic pathways of miR-155 identified in this review suggest new avenues of research for this oncogenic miRNA.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Queensland Brain Institute Publications
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Created: Mon, 30 Nov 2015, 19:25:30 EST by Rachel Suetani on behalf of Queensland Brain Institute