Survival outcomes in patients with multiple primary melanomas

Rowe, C. J., Law, M. H., Palmer, J. M., MacGregor, S., Hayward, N. K. and Khosrotehrani, K. (2015) Survival outcomes in patients with multiple primary melanomas. Journal of the European Academy of Dermatology and Venereology, 29 11: 2120-2127. doi:10.1111/jdv.13144

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Author Rowe, C. J.
Law, M. H.
Palmer, J. M.
MacGregor, S.
Hayward, N. K.
Khosrotehrani, K.
Title Survival outcomes in patients with multiple primary melanomas
Journal name Journal of the European Academy of Dermatology and Venereology   Check publisher's open access policy
ISSN 1468-3083
0926-9959
Publication date 2015-11-01
Year available 2015
Sub-type Article (original research)
DOI 10.1111/jdv.13144
Open Access Status Not Open Access
Volume 29
Issue 11
Start page 2120
End page 2127
Total pages 8
Place of publication Chichester, West Sussex United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Background
A substantial number of melanoma patients will develop multiple primary melanomas (MPM). Currently, little is known about the impact of MPM on survival.

Objective
We aimed to determine whether melanoma survival is worse for patients with MPM compared to those with a single invasive primary melanoma (SPM).

Materials and methods
A cohort study was conducted. Patients were sourced from an Australian population, with follow-up information collected retrospectively from registry data. Melanoma-specific survival analysis was performed to find associated variables after adjustment for known prognostic factors, using four different models, each selecting a different index melanoma lesion.

Results
1068 stage I and II melanoma patients were followed up for a median of 24.4 years. MPM was found in 17.8% of the cohort (190 patients), more likely among males and older age groups. Other clinicopathological parameters were similar between the MPM and SPM (878 patients) cohorts. After adjustment for age, sex and Breslow thickness, MPM was a hazard for death from melanoma, across all models, reaching significance when considering the last invasive lesion as the index melanoma (HR = 2.76, P = 0.017).

Conclusion
Patients with multiple invasive lesions seem more at risk of death from melanoma, independent of known prognostic factors.
Keyword Dermatology
Dermatology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
UQ Diamantina Institute Publications
 
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